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Ribonucleotide reductase
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<StructureSection load='1xjg' size='450' side='right' caption='Class II ribonucleotide reductase dimer complex with dATP, UDP and Mg+2 ion (green) (PDB entry [[1xjg]])' scene='46/461381/Cv/1'> | <StructureSection load='1xjg' size='450' side='right' caption='Class II ribonucleotide reductase dimer complex with dATP, UDP and Mg+2 ion (green) (PDB entry [[1xjg]])' scene='46/461381/Cv/1'> | ||
== Function == | == Function == | ||
| - | '''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides<ref>PMID:16756507</ref>. There are 3 classes of RNR.<br /> | + | '''Ribonucleotide reductase''' (RNR) or '''ribonucleotide-diphosphate reductase''' catalyzes the formation of deoxyribonucleotides from ribonucleotides<ref>PMID:16756507</ref>. There are 3 classes of RNR.<br /> |
* '''Class I RNR''' is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction.<br /> | * '''Class I RNR''' is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction.<br /> | ||
* ''' Class II RNR''' reduces ribonucleotide triphosphates using coenzyme B12.<br /> | * ''' Class II RNR''' reduces ribonucleotide triphosphates using coenzyme B12.<br /> | ||
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**[[1zyz]], [[1zzd]], [[2cvs]], [[2cvt]], [[2cvu]], [[2cvv]], [[2cvw]], [[2cvx]], [[2cvy]] - yRNR R1 – yeast<BR /> | **[[1zyz]], [[1zzd]], [[2cvs]], [[2cvt]], [[2cvu]], [[2cvv]], [[2cvw]], [[2cvx]], [[2cvy]] - yRNR R1 – yeast<BR /> | ||
| - | **[[ | + | **[[1r1r]], [[1rlr]], [[1mrr]] - EcRNR R1 – ''Escherichia coli''<br /> |
| + | **[[5r1r]], [[6r1r]], [[7r1r]] - EcRNR R1 (mutant)<br /> | ||
**[[4n82]] – SsRNR – ''Streptococcus sanguinis''<br /> | **[[4n82]] – SsRNR – ''Streptococcus sanguinis''<br /> | ||
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*RNR small subunit | *RNR small subunit | ||
| - | **[[2xof]], [[3n37]], [[3n38]], [[2alx]], [[1piy]], [[1r65]], [[1mxr]], [[1jqc]], [[1jpr]], [[1av8]], [[1xik]], [[1rib]], [[4m1f]] – EcRNR R2 <BR /> | + | **[[2xof]], [[3n37]], [[3n38]], [[2alx]], [[1piy]], [[1r65]], [[1mxr]], [[1jqc]], [[1jpr]], [[1av8]], [[1xik]], [[1rib]], [[4m1f]], [[5ci4]], [[4xbw]], [[5dco]], [[5dcr]], [[5dcs]], [[5ekb]], [[4xb9]], [[4xbv]] – EcRNR R2 <BR /> |
| - | **[[1yfd]], [[1piz]], [[1pj0]], [[1pj1]], [[1pm2]], [[1pim]], [[1piu]], [[1biq]], [[2av8]], [[1pfr]] - EcRNR R2 (mutant) + Fe<BR /> | + | **[[1yfd]], [[1piz]], [[1pj0]], [[1pj1]], [[1pm2]], [[1pim]], [[1piu]], [[1biq]], [[2av8]], [[1pfr]], [[5ci0]], [[5ci1]], [[5ci2]], [[5ci3]] - EcRNR R2 (mutant) + Fe<BR /> |
**[[3hf1]], [[2vux]], [[2uw2]], [[4djn]] – hRNR M2<BR /> | **[[3hf1]], [[2vux]], [[2uw2]], [[4djn]] – hRNR M2<BR /> | ||
**[[3mjo]], [[3dhz]], [[1oqu]], [[1kgn]], [[1kgo]], [[1kgp]] – RNR R2 – ''Corynebacterium ammoniagenes''<BR /> | **[[3mjo]], [[3dhz]], [[1oqu]], [[1kgn]], [[1kgo]], [[1kgp]] – RNR R2 – ''Corynebacterium ammoniagenes''<BR /> | ||
Revision as of 22:53, 27 September 2017
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3D Structures of Ribonucleotide reductase
Updated on 27-September-2017
References
- ↑ Nordlund P, Reichard P. Ribonucleotide reductases. Annu Rev Biochem. 2006;75:681-706. PMID:16756507 doi:http://dx.doi.org/10.1146/annurev.biochem.75.103004.142443
- ↑ Munro JB, Silva JC. Ribonucleotide reductase as a target to control apicomplexan diseases. Curr Issues Mol Biol. 2012;14(1):9-26. Epub 2011 Jul 26. PMID:21791713
- ↑ Larsson KM, Jordan A, Eliasson R, Reichard P, Logan DT, Nordlund P. Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase. Nat Struct Mol Biol. 2004 Nov;11(11):1142-9. Epub 2004 Oct 10. PMID:15475969 doi:http://dx.doi.org/10.1038/nsmb838
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