Ribosome inactivating protein
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Ribosome inactivating protein from pokeweed complex with adenine (PDB code [[1qci]])' scene='70/706276/Cv/1'> |
== Function == | == Function == | ||
'''Ribosome inactivating protein''' (RIP) is a bacterial or plant toxin which inhibits protein synthesis. RIP inactivates the ribosomal 60S subunit by N-glycosidic cleavage which results in releasing a specific adenine from 28S rRNA<ref>PMID:3510899</ref>. '''Type 1 RIP''' have a single chain, while '''type 2 RIP''' (i.e., ricin, ebulin and nigrin) have two chains. '''Momorcharin''' is a RIP isolated from several plants<ref>PMID:23777339</ref>. | '''Ribosome inactivating protein''' (RIP) is a bacterial or plant toxin which inhibits protein synthesis. RIP inactivates the ribosomal 60S subunit by N-glycosidic cleavage which results in releasing a specific adenine from 28S rRNA<ref>PMID:3510899</ref>. '''Type 1 RIP''' have a single chain, while '''type 2 RIP''' (i.e., ricin, ebulin and nigrin) have two chains. '''Momorcharin''' is a RIP isolated from several plants<ref>PMID:23777339</ref>. | ||
Revision as of 07:36, 29 September 2017
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3D Structures of ribosome inactivating protein
Updated on 29-September-2017
References
- ↑ Stirpe F, Barbieri L. Ribosome-inactivating proteins up to date. FEBS Lett. 1986 Jan 20;195(1-2):1-8. PMID:3510899
- ↑ Wang S, Zheng Y, Yan J, Zhu Z, Wu Z, Ding Y. Alpha-momorcharin: a ribosome-inactivating protein from Momordica charantia, possessing DNA cleavage properties. Protein Pept Lett. 2013 Nov;20(11):1257-63. PMID:23777339
- ↑ Ng TB, Liu WK, Sze SF, Yeung HW. Action of alpha-momorcharin, a ribosome inactivating protein, on cultured tumor cell lines. Gen Pharmacol. 1994 Jan;25(1):75-7. PMID:8026716
- ↑ Kurinov IV, Myers DE, Irvin JD, Uckun FM. X-ray crystallographic analysis of the structural basis for the interactions of pokeweed antiviral protein with its active site inhibitor and ribosomal RNA substrate analogs. Protein Sci. 1999 Sep;8(9):1765-72. PMID:10493577
