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Sigma factor

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Line 47: Line 47:
**[[2k9l]], [[2k9m]] – AaSF-54 core domain - NMR<br />
**[[2k9l]], [[2k9m]] – AaSF-54 core domain - NMR<br />
**[[3mzy]] – SF-H – ''Fusobacterium nucleatum''<br />
**[[3mzy]] – SF-H – ''Fusobacterium nucleatum''<br />
-
**[[1h3l]] – SF N terminal – ''Streptomyces coelicolor''<br />
+
**[[1h3l]] – ScSF N terminal – ''Streptomyces coelicolor''<br />
 +
**[[5fgm]] – ScSF SIGR region 4<br />
 +
**[[5mww]] – BsSF SIGA region 1.1 - ''Bacillus subtilis'' - NMR <br />
*Sigma factor complex with DNA
*Sigma factor complex with DNA
Line 57: Line 59:
**[[1ku7]] – EcSF region 4 (mutant) + DNA <br />
**[[1ku7]] – EcSF region 4 (mutant) + DNA <br />
**[[2o8k]], [[2o9l]] – AaSF-54 C terminal + DNA - NMR<br />
**[[2o8k]], [[2o9l]] – AaSF-54 C terminal + DNA - NMR<br />
 +
**[[5ui5]] – AaSF RpoN residues 61-398 + DNA <br />
*Sigma factor complex with protein
*Sigma factor complex with protein
Line 63: Line 66:
**[[1or7]] – EcSF-E + σ-E factor negative regulatory protein <br />
**[[1or7]] – EcSF-E + σ-E factor negative regulatory protein <br />
**[[4lup]] – EcSF residues 3-92 + EcSF region 2 <br />
**[[4lup]] – EcSF residues 3-92 + EcSF region 2 <br />
-
**[[1tlh]] – EcSF-70 region 4 + anti-σ factor<br />
+
**[[1tlh]] – EcSF ProD region 4 + anti-σ factor<br />
-
**[[2p7v]] – EcSF-70 region 4 + regulator of σ D<br />
+
**[[2p7v]] – EcSF ProD region 4 + regulator of σ D<br />
**[[1rp3]], [[1sc5]] – AaSF-28 + anti-σ factor FLGM <br />
**[[1rp3]], [[1sc5]] – AaSF-28 + anti-σ factor FLGM <br />
 +
**[[5wuq]] – BsSF SIGW + anti-σ factor RSIW <br />
**[[3hug]] – MtSF + membrane protein – ''Mycobacterium tuberculosis''<br />
**[[3hug]] – MtSF + membrane protein – ''Mycobacterium tuberculosis''<br />
**[[4nqw]] – MtSF-K region 4 + anti-σ factor<br />
**[[4nqw]] – MtSF-K region 4 + anti-σ factor<br />
**[[4x8k]] – MtSF-A region 2 + RBPA<br />
**[[4x8k]] – MtSF-A region 2 + RBPA<br />
-
**[[3wod]], [[2a6e]], [[2cw0]] – TtSF + RNAP subunits α,β,β’,ω - ''Thermus thermophilus'' <br />
+
**[[3wod]], [[2a6e]], [[2cw0]], [[5tmf]] – TtSF + RNAP subunits α,β,β’,ω - ''Thermus thermophilus'' <br />
-
**[[4mq9]], [[2a68]], [[2a69]], [[2a6h]], [[3dxj]], [[3eql]] – TtSF-70 + RNAP subunits α,β,β’,ω + antibiotic <br />
+
**[[4mq9]], [[2a68]], [[2a69]], [[2a6h]], [[3dxj]], [[3eql]] – TtSF ProD + RNAP subunits α,β,β’,ω + antibiotic <br />
**[[2be5]] – TtSF + RNAP subunits α,β,β’,ω + inhibitor<br />
**[[2be5]] – TtSF + RNAP subunits α,β,β’,ω + inhibitor<br />
 +
**[[5tmc]] – TtSF SIGA + RNAP subunits α,β,β’,ω + protein + G4P<br />
**[[1l9u]] – TaSF region 1.1-4 + RNAP subunits α,β,β’,ω<br />
**[[1l9u]] – TaSF region 1.1-4 + RNAP subunits α,β,β’,ω<br />
-
**[[4yg2]] – EcSF-70 + RNAP subunits α,β,β’,ω <br />
+
**[[4yg2]], [[5uag]], [[5uaj]], [[5uaq]] – EcSF ProD + RNAP subunits α,β,β’,ω <br />
-
**[[4mex]], [[4kmu]], [[4kn4]], [[4kn7]] – EcSF-70 + RNAP subunits α,β,β’,ω + antibiotic <br />
+
**[[5ui8]] – EcSF-45 + RNAP subunits α,β,β’,ω <br />
-
**[[4mey]], [[4ljz]], [[4lk1]] – EcSF-70 + RNAP subunits α,β,β’,ω <br />
+
**[[4mex]], [[4kmu]], [[4kn4]], [[4kn7]], [[5uac]], [[5uah]], [[5tual]], [[4zh3]], [[4zh4]] – EcSF ProD + RNAP subunits α,β,β’,ω + antibiotic <br />
-
**[[4lk0]], [[4llg]], [[4yfk]], [[4yfn]], [[4yfx]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + RNAP inhibitor<br />
+
**[[4xsx]], [[4xsy]], [[4xsz]] – EcSF ProD + RNAP subunits α,β,β’,ω + antibiotic <br />
 +
**[[4mey]], [[4ljz]], [[4lk1]] – EcSF ProD + RNAP subunits α,β,β’,ω <br />
 +
**[[5byh]] – EcSF-45 + RNAP subunits α,β,β’,ω <br />
 +
**[[5nwt]] – EcSF-54 + RNAP subunits α,β,β’,ω <br />
 +
**[[5w1s]] – EcSF RpoD + RNAP subunits α,β,β’ + TraR<br />
 +
**[[5vsw]] – EcSF RpoD + RNAP subunits α,β,β’ + DnaK suppressor protein<br />
 +
**[[5w1t]] – EcSF RpoD + RNAP subunits α,β,β’ + RpoZ + DnaK suppressor protein<br />
 +
**[[4lk0]], [[4llg]], [[4yfk]], [[4yfn]], [[4yfx]], [[4zh2]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + RNAP inhibitor<br />
**[[4cxf]] – SF CNRH + CNRY – ''Cupriavidus metallidurans''<br />
**[[4cxf]] – SF CNRH + CNRY – ''Cupriavidus metallidurans''<br />
-
**[[4g6d]], [[4g8x]], [[4g94]] – SF-70 region 4 + Orf067 – ''Staphylococcus aureus''<br />
+
**[[4g6d]], [[4g8x]], [[4g94]] – SF ProD region 4 + Orf067 – ''Staphylococcus aureus''<br />
*Sigma factor complex with protein and DNA
*Sigma factor complex with protein and DNA
Line 84: Line 96:
**[[1rio]] - TaSF region 4 + repression protein CI + DNA<br />
**[[1rio]] - TaSF region 4 + repression protein CI + DNA<br />
**[[4oin]], [[4oip]], [[4oiq]], [[4oir]] – TtSF-A + RNAP subunits α,β,β’,ω + antibiotic + DNA<br />
**[[4oin]], [[4oip]], [[4oiq]], [[4oir]] – TtSF-A + RNAP subunits α,β,β’,ω + antibiotic + DNA<br />
-
**[[4oio]], [[4g7h]], [[4g7o]], [[4g7z]], [[4q4z]], [[4q5s]] – TtSF-A + RNAP subunits α,β,β’,ω + DNA<br />
+
**[[4oio]], [[4g7h]], [[4g7o]], [[4g7z]], [[4q4z]], [[4q5s]] – TtSF SIGA + RNAP subunits α,β,β’,ω + DNA<br />
**[[1smy]] – TtSF + RNAP subunits α,β,β’,ω + G4P<br />
**[[1smy]] – TtSF + RNAP subunits α,β,β’,ω + G4P<br />
**[[3n97]] – TaSF region 4 + RNAP subunits α + DNA<br />
**[[3n97]] – TaSF region 4 + RNAP subunits α + DNA<br />
 +
**[[4xlp]], [[4xlq]], [[5tjg]] – TaSF SIGA + RNAP subunits α,β,β’,ω + DNA <br />
**[[1l9u]], [[1l9z]] – TaSF + RNAP subunits α,β,β’,ω + DNA – Cryo EM <br />
**[[1l9u]], [[1l9z]] – TaSF + RNAP subunits α,β,β’,ω + DNA – Cryo EM <br />
-
**[[3iyd]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + catabolite gene activator + DNA<br />
+
**[[4xlr]], [[4xls]] – TaSF SIGA + RNAP subunits α,β,β’,ω + CarD-like transcriptional regulator + DNA <br />
-
**[[4jk1]], [[4jk2]], [[4jkr]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + G4P<br />
+
**[[3iyd]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + catabolite gene activator + DNA<br />
-
**[[4yln]], [[4ylo]], [[4ylp]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + DNA<br />
+
**[[4jk1]], [[4jk2]], [[4jkr]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + G4P<br />
 +
**[[4yln]], [[4ylo]], [[4ylp]] – EcSF ProD + EcRNAP subunits α,β,β’,ω + DNA<br />
 +
**[[5nss]] – EcSF-54 + EcRNAP subunits α,β,β’,ω + phage shock protein F + DNA - Cryo EM<br />
 +
**[[5nsr]] – EcSF-54 + EcRNAP subunits α,β,β’,ω + DNA - Cryo EM<br />
 +
**[[5voi]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA <br />
 +
**[[5d4c]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA + CTP + ATP<br />
 +
**[[5d4d]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA + CTP + NAD<br />
 +
**[[5d4e]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA + CTP + dephosphate-CoA<br />
 +
**[[5uha]] – MtSF SIGA + MtRNAP subunits α,β,β’,ω + DNA <br />
 +
**[[5uhe]], [[5uhf]] – MtSF SIGA + MtRNAP subunits α,β,β’,ω + DNA + inhibitor<br />
 +
**[[5uhg]] – MtSF SIGA + MtRNAP subunits α,β,β’,ω + DNA + antibiotic + inhibitor<br />
 +
**[[5uhb]] – MtSF SIGA + MtRNAP subunits α,β,β’,ω + DNA + antibiotic<br />
 +
**[[5tw1]] – MsSF SIGA + MtRNAP subunits α,β,β’,ω + DNA + peptide - ''Mycobacterium smegmatis''<br />
 +
**[[5vi8]] – MsSF SIGA + MsRNAP subunits α,β,β’,ω + DNA <br />
 +
*Sigma factor complex with protein, DNA and RNA
 +
 +
**[[5vi5]] – MsSF SIGA + MsRNAP subunits α,β,β’,ω + RbpA + DNA + RNA<br />
 +
**[[4xln]] – TaSF SIGA + RNAP subunits α,β,β’,ω + DNA + RNA <br />
 +
**[[5ipl]], [[5ipm]], [[5ipn]] – EcSF RpoS + EcRNAP subunits α,β,β’,ω + DNA + RNA<br />
 +
**[[5e17]], [[5e18]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA + RNA<br />
 +
**[[5x22]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA + RNA + CMPPP<br />
 +
**[[5vo8]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA + RNA + GTP<br />
 +
**[[5i2d]] – TtSF SIGA + TtRNAP subunits α,β,β’,ω + transcriptional regulator + DNA + RNA<br />
 +
**[[5uh5]], [[5uh8]], [[5uh9]] – MtSF SIGA + MtRNAP subunits α,β,β’,ω + DNA + RNA<br />
 +
**[[5uh6]], [[5uhc]], [[5uhd]], [[5x21]] – MtSF SIGA + TtRNAP subunits α,β,β’,ω + DNA + RNA + antibiotic<br />
}}
}}
== References ==
== References ==

Revision as of 18:49, 4 October 2017

Structure of sigma factor of E.Coli RNAP (grey) in complex with Promoter DNA (green) and ethylene glycol (PDB code 4lup).

Drag the structure with the mouse to rotate

3D structures of sigma factor

Updated on 04-October-2017

References

1. Felklistov, Andrey, Brian D. Sharon, Seth A. Darst, and Carol A. Gross. "Bacterial Sigma Factors: A Historical, Structural, and Genomic Perspective." The Annual Review of Microbiology 68 (2014): 357-76.

2. Voet, Donald, Judith G. Voet, and Charlotte W. Pratt. Fundamentals of Biochemistry: Life at the Molecular Level. 3rd ed. Hoboken, NJ: Wiley, 2008.

3. Mooney, R. A., S. A. Darst, and R. Landick. "Sigma and RNA Polymerase: An On-again, Off-again Relationship?" Molecular Cell 20.3 (2005): 335-45.


Proteopedia Page Contributors and Editors (what is this?)

Wally Novak, Michal Harel

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