5jno

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m (Protected "5jno" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5jno is ON HOLD until Paper Publication
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==Crystal structure of the BD1-NTPR complex from BEND3 and PICH==
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<StructureSection load='5jno' size='340' side='right' caption='[[5jno]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors: Pitchai, G., Mesa, P., Hickson, I.D., Montoya, G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5jno]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JNO FirstGlance]. <br>
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Description: Crystal structure of the BD1-NTPR complex from BEND3 and PICH
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jno OCA], [http://pdbe.org/5jno PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jno RCSB], [http://www.ebi.ac.uk/pdbsum/5jno PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jno ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/BEND3_HUMAN BEND3_HUMAN]] Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity).[UniProtKB:Q6PAL0]<ref>PMID:21914818</ref> <ref>PMID:26100909</ref> [[http://www.uniprot.org/uniprot/ERC6L_HUMAN ERC6L_HUMAN]] DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.<ref>PMID:17218258</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: DNA helicase]]
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[[Category: Hickson, I D]]
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[[Category: Mesa, P]]
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[[Category: Montoya, G]]
[[Category: Pitchai, G]]
[[Category: Pitchai, G]]
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[[Category: Hickson, I.D]]
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[[Category: Anaphase]]
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[[Category: Montoya, G]]
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[[Category: Cell cycle]]
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[[Category: Mesa, P]]
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[[Category: Sister chromatids separation]]
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[[Category: Ultra fine chromatin bridge]]

Revision as of 05:17, 6 October 2017

Crystal structure of the BD1-NTPR complex from BEND3 and PICH

5jno, resolution 2.20Å

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