5t2t
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease bound to compound L742001== | |
| - | + | <StructureSection load='5t2t' size='340' side='right' caption='[[5t2t]], [[Resolution|resolution]] 1.97Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5t2t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T2T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T2T FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0N8:(2Z)-4-[1-BENZYL-4-(4-CHLOROBENZYL)PIPERIDIN-4-YL]-2-HYDROXY-4-OXOBUT-2-ENOIC+ACID'>0N8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t2t OCA], [http://pdbe.org/5t2t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t2t RCSB], [http://www.ebi.ac.uk/pdbsum/5t2t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t2t ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/A0A059U382_9VIRU A0A059U382_9VIRU]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.[PIRNR:PIRNR000836] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: RNA-directed RNA polymerase]] | ||
| + | [[Category: Alvarez, K]] | ||
| + | [[Category: Canard, B]] | ||
| + | [[Category: Ferron, F]] | ||
| + | [[Category: Saez-Ayala, M]] | ||
| + | [[Category: Yekwa, E L]] | ||
| + | [[Category: Endonuclease]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Lcmv]] | ||
| + | [[Category: Mammarenavirus]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 05:26, 6 October 2017
Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease bound to compound L742001
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