5t3p
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7== | |
| - | + | <StructureSection load='5t3p' size='340' side='right' caption='[[5t3p]], [[Resolution|resolution]] 2.03Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5t3p]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T3P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t3p OCA], [http://pdbe.org/5t3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t3p RCSB], [http://www.ebi.ac.uk/pdbsum/5t3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t3p ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NUDT7_HUMAN NUDT7_HUMAN]] Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Burgess-Brown, N]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Elkins, J M]] | ||
[[Category: Huber, K]] | [[Category: Huber, K]] | ||
| - | [[Category: | + | [[Category: Kopec, J]] |
[[Category: Mathea, S]] | [[Category: Mathea, S]] | ||
| - | + | [[Category: Nunez, C A]] | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | [[Category: Nunez, C | + | |
[[Category: Siejka, P]] | [[Category: Siejka, P]] | ||
| - | [[Category: | + | [[Category: Srikannathasan, V]] |
[[Category: Tallant, C]] | [[Category: Tallant, C]] | ||
| - | [[Category: | + | [[Category: Coa hydrolase]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
Revision as of 05:26, 6 October 2017
Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7
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