5l1c
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Heteronuclear Solution Structure of Chlorotoxin== | |
| - | + | <StructureSection load='5l1c' size='340' side='right' caption='[[5l1c]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5l1c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L1C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1chl|1chl]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l1c OCA], [http://pdbe.org/5l1c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l1c RCSB], [http://www.ebi.ac.uk/pdbsum/5l1c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l1c ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CTXL_LEIQU CTXL_LEIQU]] This toxin binds to the surface of glioma cells, and inhibits their proliferation without having effects on normal brain cells. In this context, this toxin has been described as a chloride channel inhibitor (probably ClC-3/CLCN3) by causing its internalization via caveolae (PubMed:16520829). It has also been described to selectively interact with MMP2 (in complex with MT1-MMP (MMP14) and TIMP2), to inhibit its enzymatic activity and to decrease its presence at the cell surface (PubMed:12454020).<ref>PMID:12454020</ref> <ref>PMID:16520829</ref> <ref>PMID:8383429</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Braga, C B]] | ||
| + | [[Category: Mobli, M]] | ||
| + | [[Category: Sharma, G]] | ||
| + | [[Category: Peptide disulfide rich peptide]] | ||
| + | [[Category: Scorpion toxin]] | ||
| + | [[Category: Toxin]] | ||
| + | [[Category: Venom]] | ||
Revision as of 10:33, 7 October 2017
Heteronuclear Solution Structure of Chlorotoxin
| |||||||||||
