5uui

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'''Unreleased structure'''
 
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The entry 5uui is ON HOLD until Paper Publication
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==Crystal Structure of Spin-Labeled T77C TNFa==
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<StructureSection load='5uui' size='340' side='right' caption='[[5uui]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5uui]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UUI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTN:S-[(1-OXYL-2,2,5,5-TETRAMETHYL-2,5-DIHYDRO-1H-PYRROL-3-YL)METHYL]+METHANESULFONOTHIOATE'>MTN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uui OCA], [http://pdbe.org/5uui PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uui RCSB], [http://www.ebi.ac.uk/pdbsum/5uui PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uui ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN]] Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:[http://omim.org/entry/607507 607507]]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
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== Function ==
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[[http://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN]] Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.<ref>PMID:16829952</ref> The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.<ref>PMID:16829952</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Double electron-electron resonance in conjunction with site-directed spin labeling has been used to probe natural conformational sampling of the human tumor necrosis factor alpha trimer. We suggest a previously unreported, predeoligomerization conformation of the trimer that has been shown to be sampled at low frequency. A model of this trimeric state has been constructed based on crystal structures using the double-electron-electron-resonance distances. The model shows one of the protomers to be rotated and tilted outward at the tip end, leading to a breaking of the trimerous symmetry and distortion at a receptor-binding interface. The new structure offers opportunities to modulate the biological activity of tumor necrosis factor alpha through stabilization of the distorted trimer with small molecules.
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Authors:
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Natural Conformational Sampling of Human TNFalpha Visualized by Double Electron-Electron Resonance.,Carrington B, Myers WK, Horanyi P, Calmiano M, Lawson ADG Biophys J. 2017 Jul 25;113(2):371-380. doi: 10.1016/j.bpj.2017.06.007. PMID:28746848<ref>PMID:28746848</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 5uui" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Ceska, T]]
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[[Category: Dranow, D M]]
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[[Category: Horanyi, P S]]
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[[Category: Cytokine]]
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[[Category: Immune system]]
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[[Category: T77c]]
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[[Category: Tnf alpha]]
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[[Category: Tnfa]]

Revision as of 12:45, 7 October 2017

Crystal Structure of Spin-Labeled T77C TNFa

5uui, resolution 1.40Å

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