Thymidylate kinase
From Proteopedia
(Difference between revisions)
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**[[2cck]], [[4f4i]] – SaTMK – ''Staphylococcus aureus'' <br /> | **[[2cck]], [[4f4i]] – SaTMK – ''Staphylococcus aureus'' <br /> | ||
| - | **[[2pbr]], [[4s2e]] – AaTMK – ''Aquifex aeolicus'' <br /> | + | **[[2pbr]], [[4s2e]], [[5h5b]] – AaTMK – ''Aquifex aeolicus'' <br /> |
| + | **[[5xb5]], [[5xbh]] – AaTMK (mutant) <br /> | ||
**[[2plr]] – TMK – ''Sulfolobus tokodaii'' <br /> | **[[2plr]] – TMK – ''Sulfolobus tokodaii'' <br /> | ||
**[[3ld9]] – TMK – ''Ehrlichia chafeensis''<br /> | **[[3ld9]] – TMK – ''Ehrlichia chafeensis''<br /> | ||
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**[[2yof]], [[2yog]], [[2yoh]] - TMK + thymidine analog – ''Plasmodium falciparum''<br /> | **[[2yof]], [[2yog]], [[2yoh]] - TMK + thymidine analog – ''Plasmodium falciparum''<br /> | ||
**[[4s35]] – AaTMK + dTMP + AMPPCP<br /> | **[[4s35]] – AaTMK + dTMP + AMPPCP<br /> | ||
| + | **[[5h56]] – AaTMK + dTDP + ADP<br /> | ||
| + | **[[5xb2]], [[5xb3]] – AaTMK + dTMP + ADP<br /> | ||
| + | **[[5h5k]] – AaTMK + CMP + ATP<br /> | ||
| + | **[[5xai]] – AaTMK + TMP <br /> | ||
| + | **[[5uiv]] - TMK + TMP + ADP – ''Candida albicans''<br /> | ||
*Other thymidylate kinase binary complexes | *Other thymidylate kinase binary complexes | ||
Revision as of 18:30, 10 October 2017
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3D Structures of thymidylate kinase
Updated on 10-October-2017
References
- ↑ Cui Q, Shin WS, Luo Y, Tian J, Cui H, Yin D. Thymidylate kinase: an old topic brings new perspectives. Curr Med Chem. 2013;20(10):1286-305. PMID:23394555
- ↑ Wohrl BM, Loubiere L, Brundiers R, Goody RS, Klatzmann D, Konrad M. Expressing engineered thymidylate kinase variants in human cells to improve AZT phosphorylation and human immunodeficiency virus inhibition. J Gen Virol. 2005 Mar;86(Pt 3):757-64. PMID:15722537 doi:http://dx.doi.org/10.1099/vir.0.80529-0
- ↑ Martinez-Botella G, Breen JN, Duffy JE, Dumas J, Geng B, Gowers IK, Green OM, Guler S, Hentemann MF, Hernandez-Juan FA, Joseph-McCarthy D, Kawatkar SP, Larsen NA, Lazari O, Loch JT, Macritchie JA, McKenzie AR, Newman JV, Olivier NB, Otterson LG, Owens AP, Read J, Sheppard DW, Keating TA. Discovery of Selective and Potent Inhibitors of Gram-positive Bacterial Thymidylate Kinase (TMK). J Med Chem. 2012 Oct 8. PMID:23043329 doi:http://dx.doi.org/10.1021/jm3011806
- ↑ Ostermann N, Lavie A, Padiyar S, Brundiers R, Veit T, Reinstein J, Goody RS, Konrad M, Schlichting I. Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP. J Mol Biol. 2000 Nov 17;304(1):43-53. PMID:11071809 doi:10.1006/jmbi.2000.4175
