1yho
From Proteopedia
(Difference between revisions)
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|PDB= 1yho |SIZE=350|CAPTION= <scene name='initialview01'>1yho</scene> | |PDB= 1yho |SIZE=350|CAPTION= <scene name='initialview01'>1yho</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> | + | |LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TRR:2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM'>TRR</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1kms|1KMS]], [[1kmv|1KMV]], [[1lud|1LUD]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yho OCA], [http://www.ebi.ac.uk/pdbsum/1yho PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yho RCSB]</span> | ||
}} | }} | ||
'''Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures''' | '''Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures''' | ||
| - | |||
| - | ==Disease== | ||
| - | Known disease associated with this structure: Anemia, megaloblastic, due to DHFR deficiency (1) OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=126060 126060]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Birdsall, B.]] | [[Category: Birdsall, B.]] | ||
[[Category: Polshakov, V I.]] | [[Category: Polshakov, V I.]] | ||
| - | [[Category: NDP]] | ||
| - | [[Category: TRR]] | ||
[[Category: dhfr]] | [[Category: dhfr]] | ||
[[Category: inhibitor/enzyme complex]] | [[Category: inhibitor/enzyme complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:07:36 2008'' |
Revision as of 22:07, 30 March 2008
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| Ligands: | , | ||||||
| Activity: | Dihydrofolate reductase, with EC number 1.5.1.3 | ||||||
| Related: | 1KMS, 1KMV, 1LUD
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures
About this Structure
1YHO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH., Kovalevskaya NV, Smurnyy YD, Polshakov VI, Birdsall B, Bradbury AF, Frenkiel T, Feeney J, J Biomol NMR. 2005 Sep;33(1):69-72. PMID:16222560
Page seeded by OCA on Mon Mar 31 01:07:36 2008
