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Tryptophan synthase

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Line 37: Line 37:
**[[1x1q]] - TtTrpS β subunit – ''Thermus thermophilus''<br />
**[[1x1q]] - TtTrpS β subunit – ''Thermus thermophilus''<br />
**[[2dh6]] - EcTrpS β subunit]] - ''Escherichia coli''<br />
**[[2dh6]] - EcTrpS β subunit]] - ''Escherichia coli''<br />
-
**[[2o2e]], [[2o2j]] - TrpS β subunit – ''Mycobacterium tuberculosis''<br />
+
**[[2o2e]], [[2o2j]] - MtTrpS β subunit – ''Mycobacterium tuberculosis''<br />
**[[1v8z]] - PfTrpS β subunit <br />
**[[1v8z]] - PfTrpS β subunit <br />
**[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br />
**[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br />
**[[4qys]] - TrpS β subunit – ''Sulfolobus solfataricus''<br />
**[[4qys]] - TrpS β subunit – ''Sulfolobus solfataricus''<br />
-
*Tryptophan synthase β binary complex
+
*Tryptophan synthase β complex
**[[2dh5]] - EcTrpS β subunit + PLP<br />
**[[2dh5]] - EcTrpS β subunit + PLP<br />
 +
**[[5dvz]] - PfTrpS β subunit + PLP derivative <br />
 +
**[[5dw0]] - PfTrpS β subunit + Ser derivative <br />
 +
**[[5dw3]] - PfTrpS β subunit + PLP derivative + Trp<br />
 +
**[[5t6m]] - PfTrpS β subunit + PLP derivative + Trp derivative<br />
 +
**[[5vm5]] - PfTrpS β subunit + PLP derivative + Ser derivative<br />
 +
**[[5ixj]] - PfTrpS β subunit + PLP derivative + Thr<br />
*'''Tryptophan synthase α+β subunits'''
*'''Tryptophan synthase α+β subunits'''
Line 62: Line 68:
**[[5kzm]] - TrpS α + β + PLP derivative – ''Francisella tularensis''<br />
**[[5kzm]] - TrpS α + β + PLP derivative – ''Francisella tularensis''<br />
**[[5kin]] - TrpS α + β + PLP derivative – ''Streptococcus pneumoniae''<br />
**[[5kin]] - TrpS α + β + PLP derivative – ''Streptococcus pneumoniae''<br />
 +
**[[5e0k]] - PfTrpS α + β + PLP derivative <br />
 +
**[[5ocw]], [[5tcg]], [[5tci]], [[5tcj]] - MtTrpS α + β + inhibitor<br />
 +
**[[5tcf]] - MtTrpS α + β + PLP derivative <br />
 +
**[[5tch]] - MtTrpS α + β (mutant) + PLP derivative <br />
**[[5e0k]] - PfTrpS α + β + PLP derivative <br />
**[[5e0k]] - PfTrpS α + β + PLP derivative <br />
*Tryptophan synthase α+β ternary complex with PLP and inhibitor
*Tryptophan synthase α+β ternary complex with PLP and inhibitor
-
**[[1a50]], [[1cw2]], [[1c9d]], [[1cx9]], [[1c8v]], [[1c29]], [[2cle]], [[2clh]], [[2cli]], [[2clk]], [[2cll]], [[2clm]], [[2clo]], [[2clf]], [[5bw6]], [[4zqc]], [[4y6g]], [[4xug]], [[4wx2]] - StTrpS α + β + inhibitor + PLP<br />
+
**[[1a50]], [[1cw2]], [[1c9d]], [[1cx9]], [[1c8v]], [[1c29]], [[2cle]], [[2clh]], [[2cli]], [[2clk]], [[2cll]], [[2clm]], [[2clo]], [[2clf]], [[5bw6]], [[4zqc]], [[4y6g]], [[4xug]], [[4wx2]], [[5bw6]] - StTrpS α + β + inhibitor + PLP<br />
**[[5cgq]] - StTrpS α + β + inhibitor + PLP + Trp<br />
**[[5cgq]] - StTrpS α + β + inhibitor + PLP + Trp<br />
**[[1fuy]] - StTrpS α + β (mutant) + inhibitor + PLP<br />
**[[1fuy]] - StTrpS α + β (mutant) + inhibitor + PLP<br />
Line 93: Line 103:
**[[1a5s]] - StTrpS α + β + serine + inhibitor + PLP<br />
**[[1a5s]] - StTrpS α + β + serine + inhibitor + PLP<br />
 +
**[[5cgq]] - StTrpS α + β + Trp + inhibitor + PLP<br />
**[[3cep]] - StTrpS α + β + G3P + indoline + PLP<br />
**[[3cep]] - StTrpS α + β + G3P + indoline + PLP<br />
}}
}}

Revision as of 22:57, 11 October 2017

Tryptophan synthase α subunit (yellow, salmon) and β subunit (cyan, magenta) of the α2β2 tetramer complex with pyridoxal-phosphate, glycerol-3-phosphate and Na+ ion (purple) 1wbj

Drag the structure with the mouse to rotate

3D structures of tryptophan synthase

Updated on 11-October-2017

References

  1. ↑ Miles EW. Tryptophan synthase: a multienzyme complex with an intramolecular tunnel. Chem Rec. 2001;1(2):140-51. PMID:11893063
  2. ↑ Shen H, Yang Y, Wang F, Zhang Y, Ye N, Xu S, Wang H. Characterization of the putative tryptophan synthase beta-subunit from Mycobacterium tuberculosis. Acta Biochim Biophys Sin (Shanghai). 2009 May;41(5):379-88. PMID:19430702
  3. ↑ Kulik V, Hartmann E, Weyand M, Frey M, Gierl A, Niks D, Dunn MF, Schlichting I. On the structural basis of the catalytic mechanism and the regulation of the alpha subunit of tryptophan synthase from Salmonella typhimurium and BX1 from maize, two evolutionarily related enzymes. J Mol Biol. 2005 Sep 23;352(3):608-20. PMID:16120446 doi:10.1016/j.jmb.2005.07.014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Amer Ali

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