1yia
From Proteopedia
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|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=HRP:5-HYDROXY-L-TRYPTOPHAN'>HRP</scene> | |LIGAND= <scene name='pdbligand=HRP:5-HYDROXY-L-TRYPTOPHAN'>HRP</scene> | ||
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Tryptophan--tRNA_ligase Tryptophan--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.2 6.1.1.2] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan--tRNA_ligase Tryptophan--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.2 6.1.1.2] </span> |
|GENE= DR1093 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243230 Deinococcus radiodurans R1]) | |GENE= DR1093 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243230 Deinococcus radiodurans R1]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1yi8|1YI8]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yia OCA], [http://www.ebi.ac.uk/pdbsum/1yia PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yia RCSB]</span> | ||
}} | }} | ||
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[[Category: Buddha, M R.]] | [[Category: Buddha, M R.]] | ||
[[Category: Crane, B R.]] | [[Category: Crane, B R.]] | ||
| - | [[Category: HRP]] | ||
[[Category: 5 hydroxy tryptophan]] | [[Category: 5 hydroxy tryptophan]] | ||
[[Category: trna synthetase]] | [[Category: trna synthetase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:08:24 2008'' |
Revision as of 22:08, 30 March 2008
| |||||||
| , resolution 3.7Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | DR1093 (Deinococcus radiodurans R1) | ||||||
| Activity: | Tryptophan--tRNA ligase, with EC number 6.1.1.2 | ||||||
| Related: | 1YI8
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of tryptophanyl tRNA synthetase II from Deinococcus radiodurans in complex with 5-Hydroxy tryptophan.
Overview
The most divergent of two tryptophanyl tRNA synthetases (TrpRS II) found in Deinococcus radiodurans interacts with a nitric oxide synthase protein that produces 4-nitro-tryptophan (4-NRP). TrpRS II efficiently charges transfer RNA(Trp) with 4-NRP and 5-hydroxy-tryptophan (5-HRP). The crystal structures of TrpRS II bound to tryptophan and 5-HRP reveal residue substitutions that accommodate modified indoles. A class of auxiliary bacterial TrpRSs conserve this capacity to charge tRNA with nonstandard amino acids.
About this Structure
1YIA is a Single protein structure of sequence from Deinococcus radiodurans r1. Full crystallographic information is available from OCA.
Reference
Structure and activity of an aminoacyl-tRNA synthetase that charges tRNA with nitro-tryptophan., Buddha MR, Crane BR, Nat Struct Mol Biol. 2005 Mar;12(3):274-5. Epub 2005 Feb 20. PMID:15723076
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