2a11

From Proteopedia

(Difference between revisions)

Revision as of 10:07, 12 October 2017

Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis

Structural highlights

2a11 is a 1 chain structure with sequence from "bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	rnc ("Bacillus tuberculosis" (Zopf 1883) Klein 1884)
Activity:	Ribonuclease III, with EC number 3.1.26.3
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RNC_MYCTU] Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism (By similarity).[HAMAP-Rule:MF_00104]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

RNase III enzymes are a highly conserved family of proteins that specifically cleave double-stranded (ds)RNA. These proteins are involved in a diverse group of functions, including ribosomal RNA processing, mRNA maturation and decay, snRNA and snoRNA processing, and RNA interference. Here we report the crystal structure of the nuclease domain of RNase III from the pathogen Mycobacterium tuberculosis. Although globally similar to other RNase III folds, this structure has some features not observed in previously reported models. These include the presence of an additional metal ion near the catalytic site, as well as conserved secondary structural elements that are proposed to have functional roles in the recognition of dsRNAs.

Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A.,Akey DL, Berger JM Protein Sci. 2005 Oct;14(10):2744-50. Epub 2005 Sep 9. PMID:16155207^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Akey DL, Berger JM. Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A. Protein Sci. 2005 Oct;14(10):2744-50. Epub 2005 Sep 9. PMID:16155207 doi:10.1110/ps.051665905

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2a11"

@@ Line 1: / Line 1: @@
 ==Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis==
 <StructureSection load='2a11' size='340' side='right' caption='[[2a11]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
@@ Line 6: / Line 7: @@
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rnc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
 <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a11 OCA], [http://pdbe.org/2a11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a11 RCSB], [http://www.ebi.ac.uk/pdbsum/2a11 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a11 OCA], [http://pdbe.org/2a11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a11 RCSB], [http://www.ebi.ac.uk/pdbsum/2a11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2a11 ProSAT]</span></td></tr>
 </table>
 == Function ==

2a11

From Proteopedia

Revision as of 10:07, 12 October 2017

Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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