1ykb

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|PDB= 1ykb |SIZE=350|CAPTION= <scene name='initialview01'>1ykb</scene>, resolution 2.60&Aring;
|PDB= 1ykb |SIZE=350|CAPTION= <scene name='initialview01'>1ykb</scene>, resolution 2.60&Aring;
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+
|LIGAND= <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= IL22, ILTIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= IL22, ILTIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
|DOMAIN=
 +
|RELATEDENTRY=
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ykb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ykb OCA], [http://www.ebi.ac.uk/pdbsum/1ykb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ykb RCSB]</span>
}}
}}
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[[Category: Walter, M R.]]
[[Category: Walter, M R.]]
[[Category: Xu, T.]]
[[Category: Xu, T.]]
-
[[Category: NAG]]
 
[[Category: cytokine]]
[[Category: cytokine]]
[[Category: glycosylation]]
[[Category: glycosylation]]
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[[Category: interleukin]]
[[Category: interleukin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:24:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:10:33 2008''

Revision as of 22:10, 30 March 2008

Image:1ykb.gif


PDB ID 1ykb

Drag the structure with the mouse to rotate
, resolution 2.60Å
Ligands: , ,
Gene: IL22, ILTIF (Homo sapiens)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Insect Cell Expressed IL-22


Overview

The crystal structure of interleukin-22 expressed in Drosophila melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution. IL-22(Dm) crystals contain six molecules in the asymmetric unit. Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in Escherichia coli) structures reveals that N-linked glycosylation causes only minor structural changes to the cytokine. However, 1-4 A main-chain differences are observed between the six IL-22(Dm) monomers at regions corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of the carbohydrate and the conformational variation of IL22(Dm) provide new insights into IL-22 receptor recognition.

About this Structure

1YKB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of insect-cell-derived IL-22., Xu T, Logsdon NJ, Walter MR, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):942-50. Epub 2005, Jun 24. PMID:15983417

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