1m4r

From Proteopedia

(Difference between revisions)

Revision as of 11:18, 12 October 2017

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22

Structural highlights

1m4r is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[IL22_HUMAN] Cytokine that contributes to the inflammatory response in vivo.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Interleukin-22 (IL-10-related T cell-derived inducible factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family. Recombinant human IL-22 (hIL-22) was found to activate the signal transducers and activators of transcription factors 1 and 3 as well as acute phase reactants in several hepatoma cell lines, suggesting its involvement in the inflammatory response. The crystallographic structure of recombinant hIL-22 has been solved at 2.0 A resolution using the SIRAS method. Contrary to IL-10, the hIL-22 dimer does not present an interpenetration of the secondary-structure elements belonging to the two distinct polypeptide chains but results from interface interactions between monomers. Structural differences between these two cytokines, revealed by the crystallographic studies, clearly indicate that, while a homodimer of IL-10 is required for signaling, hIL-22 most probably interacts with its receptor as a monomer.

Crystal structure of recombinant human interleukin-22.,Nagem RA, Colau D, Dumoutier L, Renauld JC, Ogata C, Polikarpov I Structure. 2002 Aug;10(8):1051-62. PMID:12176383^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Nagem RA, Colau D, Dumoutier L, Renauld JC, Ogata C, Polikarpov I. Crystal structure of recombinant human interleukin-22. Structure. 2002 Aug;10(8):1051-62. PMID:12176383

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m4r"

@@ Line 1: / Line 1: @@
 ==CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22==
 <StructureSection load='1m4r' size='340' side='right' caption='[[1m4r]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[1m4r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M4R FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4r OCA], [http://pdbe.org/1m4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m4r RCSB], [http://www.ebi.ac.uk/pdbsum/1m4r PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4r OCA], [http://pdbe.org/1m4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m4r RCSB], [http://www.ebi.ac.uk/pdbsum/1m4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4r ProSAT]</span></td></tr>
 </table>
 == Function ==

1m4r

From Proteopedia

Revision as of 11:18, 12 October 2017

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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