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1ymf

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|PDB= 1ymf |SIZE=350|CAPTION= <scene name='initialview01'>1ymf</scene>, resolution 2.6&Aring;
|PDB= 1ymf |SIZE=350|CAPTION= <scene name='initialview01'>1ymf</scene>, resolution 2.6&Aring;
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>
+
|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
 +
|DOMAIN=
 +
|RELATEDENTRY=[[1yks|1YKS]]
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ymf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ymf OCA], [http://www.ebi.ac.uk/pdbsum/1ymf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ymf RCSB]</span>
}}
}}
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[[Category: Smith, J L.]]
[[Category: Smith, J L.]]
[[Category: Wu, J.]]
[[Category: Wu, J.]]
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[[Category: ADP]]
 
[[Category: adp]]
[[Category: adp]]
[[Category: atpase]]
[[Category: atpase]]
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[[Category: yellow fever virus]]
[[Category: yellow fever virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 14:22:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:13:12 2008''

Revision as of 22:13, 30 March 2008

Image:1ymf.gif


PDB ID 1ymf

Drag the structure with the mouse to rotate
, resolution 2.6Å
Ligands: ,
Related: 1YKS


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



crystal structure of yellow fever virus NS3 helicase complexed with ADP


Overview

Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes residues 187 to 623. Two familiar helicase domains bind nucleotide in a triphosphate pocket without base recognition, providing a site for nonspecific hydrolysis of nucleoside triphosphates and RNA triphosphate. The third, C-terminal domain has a unique structure and is proposed to function in RNA and protein recognition. The organization of the three domains indicates that cleavage of the viral polyprotein NS3-NS4A junction occurs in trans.

About this Structure

1YMF is a Single protein structure of sequence from Yellow fever virus. Full crystallographic information is available from OCA.

Reference

Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing., Wu J, Bera AK, Kuhn RJ, Smith JL, J Virol. 2005 Aug;79(16):10268-77. PMID:16051820

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