Tubulin
From Proteopedia
(Difference between revisions)
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**[[1tub]] - pTUBA+pTUBB – electron diffraction<br /> | **[[1tub]] - pTUBA+pTUBB – electron diffraction<br /> | ||
**[[2btq]] – PdTUBA+PdTUBB<br /> | **[[2btq]] – PdTUBA+PdTUBB<br /> | ||
| + | **[[5w3f]] - yTUBA+yTUBB + GDP + GTP - yeast<br /> | ||
| + | **[[5w3j]] - yTUBA+yTUBB (mutant) + GDP + GTP + taxol<br /> | ||
| + | **[[5ubq]], [[5ucy]] - TUBA+ TUBB – ''Tetrahymena thermophila'' - Cryo EM <br /> | ||
*α-tubulin + β-tubulin complexes with stathmin | *α-tubulin + β-tubulin complexes with stathmin | ||
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**[[4eb6]] - sTUBA+sTUBB+stathmin-4<br /> | **[[4eb6]] - sTUBA+sTUBB+stathmin-4<br /> | ||
**[[4x1i]], [[4x1k]], [[4x1y]], [[4x20]] - sTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + dolastatin + colchicine<br /> | **[[4x1i]], [[4x1k]], [[4x1y]], [[4x20]] - sTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + dolastatin + colchicine<br /> | ||
| + | **[[5kx5]] - sTUBA+sTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ADP + inhibitor<br /> | ||
**[[5eyp]] - sTUBA+sTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + colchicine<br /> | **[[5eyp]] - sTUBA+sTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + colchicine<br /> | ||
| - | **[[4f6r]] - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein | + | **[[4f6r]] - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein<br /> |
**[[5lp6]] – bTUBA1B +bTUBB2B +stathmin-4 + protein<br /> | **[[5lp6]] – bTUBA1B +bTUBB2B +stathmin-4 + protein<br /> | ||
**[[3du7]], [[3e22]], [[1z2b]], [[1sa0]], [[1sa1]], [[1ffx]] – bTUBA1C+bTUBB2B+stathmin-4<br /> | **[[3du7]], [[3e22]], [[1z2b]], [[1sa0]], [[1sa1]], [[1ffx]] – bTUBA1C+bTUBB2B+stathmin-4<br /> | ||
**[[4o2a]], [[4iij]], [[4i55]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase<br /> | **[[4o2a]], [[4iij]], [[4i55]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase<br /> | ||
**[[4wbn]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative<br /> | **[[4wbn]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative<br /> | ||
| - | **[[5la6]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + pironetin<br /> | ||
| - | **[[5bmv]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + vinblastine<br /> | ||
**[[5jh7]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + eribulin<br /> | **[[5jh7]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + eribulin<br /> | ||
| - | **[[5la6]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + | + | **[[5la6]], [[5m7e]], [[5bmv]], [[5lov]], [[5lxt]], [[5lxj]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5mf4]], [[5ov7]], [[5lxs]], [[5xlt]], [[5o7a]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + inhibitor<br /> |
| + | **[[5njh]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + triazolopyrimidine<br /> | ||
**[[5iyz]], [[5j2t]], [[5j2u]], [[4tv9]], [[4yj2]], [[4yj3]], [[2xrp]] – bTUBAB1 +bTUBBB2 +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + auristatin anti-mitotics<br /> | **[[5iyz]], [[5j2t]], [[5j2u]], [[4tv9]], [[4yj2]], [[4yj3]], [[2xrp]] – bTUBAB1 +bTUBBB2 +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + auristatin anti-mitotics<br /> | ||
**[[4o2b]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + colchicine<br /> | **[[4o2b]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + colchicine<br /> | ||
| - | **[[4tuy]], [[4o4h]], [[4o4i]], [[4o4j]], [[4o4l]], [[4i50]], [[4i4t]], [[4tv8]], | + | **[[4tuy]], [[4o4h]], [[4o4i]], [[4o4j]], [[4o4l]], [[4i50]], [[4i4t]], [[4tv8]], [[4zhq]], [[4zi7]], [[4zol]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + valinamide derivative<br /> |
| - | + | ||
**[[4ihj]] - bTUBA+bTUBB+stathmin-4 + tubulin Tyr-ligase + ADP<br /> | **[[4ihj]] - bTUBA+bTUBB+stathmin-4 + tubulin Tyr-ligase + ADP<br /> | ||
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**[[3dco]] - bTUBA+bTUBB+kinesin-like NOD<br /> | **[[3dco]] - bTUBA+bTUBB+kinesin-like NOD<br /> | ||
**[[4ck5]], [[4ck6]], [[4ck7]] - bTUBA+bTUBB+kinesin-like KIF11 motor domain<br /> | **[[4ck5]], [[4ck6]], [[4ck7]] - bTUBA+bTUBB+kinesin-like KIF11 motor domain<br /> | ||
| + | **[[5mio]] - bTUBA+bTUBB+kinesin-like KIF2C motor domain<br /> | ||
**[[5hnw]], [[5hnx]], [[5hny]], [[5hnz]] – bTUBAB1 +bTUBBB2 +kinesin-14 + GDP + GTP + taxol<br /> | **[[5hnw]], [[5hnx]], [[5hny]], [[5hnz]] – bTUBAB1 +bTUBBB2 +kinesin-14 + GDP + GTP + taxol<br /> | ||
**[[3edl]] - bTUBA1D+bTUBB2B+kinesin motor domain<br /> | **[[3edl]] - bTUBA1D+bTUBB2B+kinesin motor domain<br /> | ||
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**[[1ia0]] - pTUBA+pTUBB+kinesin-like KIF1A+ATP<br /> | **[[1ia0]] - pTUBA+pTUBB+kinesin-like KIF1A+ATP<br /> | ||
**[[4aqv]], [[4aqw ]]- bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM<br /> | **[[4aqv]], [[4aqw ]]- bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM<br /> | ||
| + | **[[5nd3]] - bTUBA+bTUBB+kinesin-like KIF20A + GDP + GTP – Cryo EM<br /> | ||
| + | **[[5nd2]], [[5nd4]] - bTUBA+bTUBB+kinesin-like KIF20A + GDP + GTP + ADP – Cryo EM<br /> | ||
| + | **[[5nd7]] - bTUBA+bTUBB+kinesin-like KIF20A + AMPPNP – Cryo EM<br /> | ||
**[[4atx]] - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM<br /> | **[[4atx]] - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM<br /> | ||
| + | **[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] - bTUBA1D+bTUBB2B+kinesin-5 motor domain + AMPPNP – Cryo EM<br /> | ||
| + | **[[5o09]] - TUBA+TUBB +GDP + GTP + kinesin light chain – ''Prosthecobacter dejongeii'' - Cryo EM <br /> | ||
*α-tubulin + β-tubulin other complexes | *α-tubulin + β-tubulin other complexes | ||
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**[[4abo]] - pTUBA+pTUBB+ microtubule integrity protein MAL3<br /> | **[[4abo]] - pTUBA+pTUBB+ microtubule integrity protein MAL3<br /> | ||
**[[4atu]] - bTUBA1D+bTUBB2B+doublecortin – Cryo EM<br /> | **[[4atu]] - bTUBA1D+bTUBB2B+doublecortin – Cryo EM<br /> | ||
| - | **[[4ffb]], [[4u3j]] - | + | **[[5nqu]], [[5nqt]] - bTUBA+bTUBB + ankyrin repeat protein + GDP + GTP<br /> |
| + | **[[5nm5]] - bTUBA+bTUBB + ankyrin repeat protein + GDP + GTP + colchicine<br /> | ||
| + | **[[5m50]], [[5m54]], [[5m5c]] - bTUBA+bTUBB + calmodulin-regulated spectrin-associated protein + GDP + GTP - Cryo EM<br /> | ||
| + | **[[4ffb]], [[4u3j]] - yTUBA+TUBB (mutant) + protein STU2 <br /> | ||
*γ-tubulin | *γ-tubulin | ||
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**[[2q1x]], [[1rq2]] - MtFtsZ+citrate – ''Mycobacterium tuberculosis''<br /> | **[[2q1x]], [[1rq2]] - MtFtsZ+citrate – ''Mycobacterium tuberculosis''<br /> | ||
**[[2q1y]], [[1rlu]] - MtFtsZ+GTP-gamma-S<br /> | **[[2q1y]], [[1rlu]] - MtFtsZ+GTP-gamma-S<br /> | ||
| - | **[[1rq7]], [[4kwe]] - MtFtsZ+GDP<br /> | + | **[[1rq7]], [[4kwe]], [[5v68]] - MtFtsZ+GDP<br /> |
**[[2vap]] – MjFtsZ+GDP <br /> | **[[2vap]] – MjFtsZ+GDP <br /> | ||
**[[1w58]] - MjFtsZ+GMPCPP<br /> | **[[1w58]] - MjFtsZ+GMPCPP<br /> | ||
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**[[1w5b]] - MjFtsZ+GTP<br /> | **[[1w5b]] - MjFtsZ+GTP<br /> | ||
**[[4b45]] – HvFtsZ + GTP-γS – ''Haloferax volcanii''<br /> | **[[4b45]] – HvFtsZ + GTP-γS – ''Haloferax volcanii''<br /> | ||
| - | **[[3vo8]], [[3voa]] - SaFtsZ + GDP <br /> | + | **[[3vo8]], [[3voa]], [[5h5g]] - SaFtsZ + GDP <br /> |
| - | **[[3wgl]] – SaFtsZ (mutant) + GDP<br /> | + | **[[3wgl]], [[5xdw]], [[5h5h]], [[5h5i]], [[5mn4]], [[5mn6]] – SaFtsZ (mutant) + GDP<br /> |
**[[3wgn]] – SaFtsZ + GTP-γS<br /> | **[[3wgn]] – SaFtsZ + GTP-γS<br /> | ||
| - | **[[3wgm]] – SaFtsZ (mutant) + GTP<br /> | + | **[[3wgm]], [[5mn5]], [[5mn7]], [[5mn8]] – SaFtsZ (mutant) + GTP<br /> |
| - | **[[3vob]] - SaFtsZ + GDP + | + | **[[3vob]], [[5xdt]], [[5xdu]] - SaFtsZ + GDP + inhibitor<br /> |
| + | **[[5xdv]] - SaFtsZ (mutant) + GDP + inhibitor<br /> | ||
**[[4dxd]] - SaFtsZ + antibiotic <br /> | **[[4dxd]] - SaFtsZ + antibiotic <br /> | ||
**[[4b46]] - HvFtsZ + GDP <br /> | **[[4b46]] - HvFtsZ + GDP <br /> | ||
Revision as of 18:28, 12 October 2017
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3D Structures of Tubulin
Updated on 12-October-2017
References
- ↑ Moritz M, Agard DA. Gamma-tubulin complexes and microtubule nucleation. Curr Opin Struct Biol. 2001 Apr;11(2):174-81. PMID:11297925
- ↑ Arjes HA, Lai B, Emelue E, Steinbach A, Levin PA. Mutations in the bacterial cell division protein FtsZ highlight the role of GTP binding and longitudinal subunit interactions in assembly and function. BMC Microbiol. 2015 Oct 13;15:209. doi: 10.1186/s12866-015-0544-z. PMID:26463348 doi:http://dx.doi.org/10.1186/s12866-015-0544-z
- ↑ Giarnieri E, De Francesco GP, Carico E, Midiri G, Amanti C, Giacomelli L, Tucci G, Gidaro S, Stroppa I, Gidaro G, Giovagnoli MR. Alpha- and beta-tubulin expression in rectal cancer development. Anticancer Res. 2005 Sep-Oct;25(5):3237-41. PMID:16101133
- ↑ Jaglin XH, Poirier K, Saillour Y, Buhler E, Tian G, Bahi-Buisson N, Fallet-Bianco C, Phan-Dinh-Tuy F, Kong XP, Bomont P, Castelnau-Ptakhine L, Odent S, Loget P, Kossorotoff M, Snoeck I, Plessis G, Parent P, Beldjord C, Cardoso C, Represa A, Flint J, Keays DA, Cowan NJ, Chelly J. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat Genet. 2009 Jun;41(6):746-52. doi: 10.1038/ng.380. Epub 2009 May 24. PMID:19465910 doi:http://dx.doi.org/10.1038/ng.380
