Tubulin tyrosine ligase

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*Tubulin tyrosine ligase complex with tubulin and inhibitor
*Tubulin tyrosine ligase complex with tubulin and inhibitor
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[[4o2a]], [[5fnv]], [[5ca1]] – cTTL + rSTM + tubulin + GTP + GDP + ADP + inhibitor<br />
+
**[[4o2a]], [[5fnv]], [[5ca1]] – cTTL + rSTM + tubulin + GTP + GDP + ADP + inhibitor<br />
-
[[4i4t]] – cTTL + rSTM + tubulin + GTP + GDP + zampanolide <br />
+
**[[4i50]] – cTTL + rSTM + tubulin + GTP + GDP + epothilone <br />
-
[[4i50]] – cTTL + rSTM + tubulin + GTP + GDP + epothilone <br />
+
**[[4o4l]], [[4tuy]], [[4tv8]], [[4yj2]], [[4yj3]], [[5j2t]] – cTTL + rSTM + tubulin + GTP + GDP + anti-cancer drugs<br />
-
[[4o4l]], [[4tuy]], [[4tv8]], [[4yj2]], [[4yj3]] – cTTL + rSTM + tubulin + GTP + GDP + anti-cancer drugs<br />
+
**[[4o2b]], [[5lp6]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + anti-gout drug<br />
-
[[4o2b]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + anti-gout drug<br />
+
**[[4o4h]], [[4o4j]], [[4o4i]], [[5c8y]], [[5cb4]], [[5ca1]], [[5bmv]], [[5jh7]], [[5lxt]], [[4i4t]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + anti-cancer drug<br />
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[[4o4h]], [[4o4j]], [[4o4i]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + anti-cancer drug<br />
+
**[[5iyz]], [[5j2t]], [[5j2u]], [[5la6]], [[5bmv]], [[5jh7]] – bTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor - bovine<br />
**[[5iyz]], [[5j2t]], [[5j2u]], [[5la6]], [[5bmv]], [[5jh7]] – bTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor - bovine<br />
-
**[[4zhq]], [[4zi7]], [[4zol]], [[5c8y]] – pTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor <br />
+
**[[4zhq]], [[4zi7]], [[4zol]], [[5c8y]], [[5fnv]], [[5m7g]], [[5m8d]], [[5m8g]], [[5xlt]], [[5lov]], [[5lyj]], [[5m7e]], [[5njh]], [[5lxs]] – pTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor <br />
 +
**[[5iyz]] – pTTL + rSTM + tubulin + GTP + GDP + ATP derivative + auristatin <br />
**[[5cb4]] – bpTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor – bearded pig<br />
**[[5cb4]] – bpTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor – bearded pig<br />

Revision as of 18:58, 12 October 2017

Tubulin tyrosine ligase (cyan) complex with α-tubulin (grey and pink), β-tubulin (green and yellow), stathmin (magenta), MES, GTP, Ca+2, Cl- and Mg+2 ions (PDB code 4iij)

Drag the structure with the mouse to rotate

3D Structures of tubulin tyrosine ligase

Updated on 12-October-2017

References

  1. ↑ Idriss HT. Phosphorylation of tubulin tyrosine ligase: a potential mechanism for regulation of alpha-tubulin tyrosination. Cell Motil Cytoskeleton. 2000 May;46(1):1-5. PMID:10842328 doi:<1::AID-CM1>3.0.CO;2-6 http://dx.doi.org/10.1002/(SICI)1097-0169(200005)46:1<1::AID-CM1>3.0.CO;2-6
  2. ↑ Szyk A, Piszczek G, Roll-Mecak A. Tubulin tyrosine ligase and stathmin compete for tubulin binding in vitro. J Mol Biol. 2013 Jul 24;425(14):2412-4. doi: 10.1016/j.jmb.2013.04.017. Epub 2013, Apr 25. PMID:23624152 doi:http://dx.doi.org/10.1016/j.jmb.2013.04.017
  3. ↑ Lafanechere L, Courtay-Cahen C, Kawakami T, Jacrot M, Rudiger M, Wehland J, Job D, Margolis RL. Suppression of tubulin tyrosine ligase during tumor growth. J Cell Sci. 1998 Jan;111 ( Pt 2):171-81. PMID:9405300
  4. ↑ Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO. Structural basis of tubulin tyrosination by tubulin tyrosine ligase. J Cell Biol. 2013 Feb 4;200(3):259-70. doi: 10.1083/jcb.201211017. Epub 2013 Jan , 28. PMID:23358242 doi:http://dx.doi.org/10.1083/jcb.201211017

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Michal Harel, Joel L. Sussman, Alexander Berchansky

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