5vm9
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Human Argonaute3 bound to guide RNA== | |
| - | + | <StructureSection load='5vm9' size='340' side='right' caption='[[5vm9]], [[Resolution|resolution]] 3.28Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5vm9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Insect_cell_expression_vector_ptie1 Insect cell expression vector ptie1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VM9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vm9 OCA], [http://pdbe.org/5vm9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vm9 RCSB], [http://www.ebi.ac.uk/pdbsum/5vm9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vm9 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AGO3_HUMAN AGO3_HUMAN]] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.[HAMAP-Rule:MF_03032]<ref>PMID:18771919</ref> <ref>PMID:23064648</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Insect cell expression vector ptie1]] | ||
| + | [[Category: Nakanishi, K]] | ||
| + | [[Category: Park, M S]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Hydrolase-rna complex]] | ||
| + | [[Category: Protein]] | ||
| + | [[Category: Rna binding protein-rna complex]] | ||
Revision as of 07:17, 18 October 2017
Human Argonaute3 bound to guide RNA
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