5wir
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the TRF1-TERB1 interface== | |
| - | + | <StructureSection load='5wir' size='340' side='right' caption='[[5wir]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5wir]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WIR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wir OCA], [http://pdbe.org/5wir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wir RCSB], [http://www.ebi.ac.uk/pdbsum/5wir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wir ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TERF1_HUMAN TERF1_HUMAN]] Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.<ref>PMID:16166375</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Nandakumar, J]] | ||
| + | [[Category: Pendlebury, D F]] | ||
| + | [[Category: Smith, E M]] | ||
| + | [[Category: Tesmer, V M]] | ||
| + | [[Category: Cdk phosphorylation]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Meiosis]] | ||
| + | [[Category: Telomere]] | ||
Revision as of 07:19, 18 October 2017
Structure of the TRF1-TERB1 interface
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