5wj9

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m (Protected "5wj9" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5wj9 is ON HOLD until Paper Publication
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==cryo-EM of a lysosomal protein==
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<StructureSection load='5wj9' size='340' side='right' caption='[[5wj9]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
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Authors: Schmiege, P., Li, X.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5wj9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WJ9 FirstGlance]. <br>
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Description: cryo-EM of a lysosomal protein
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AQV:2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione'>AQV</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wj9 OCA], [http://pdbe.org/5wj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wj9 RCSB], [http://www.ebi.ac.uk/pdbsum/5wj9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wj9 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/MCLN1_HUMAN MCLN1_HUMAN]] Mucolipidosis type 4. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/MCLN1_HUMAN MCLN1_HUMAN]] Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis.<ref>PMID:12459486</ref> <ref>PMID:14749347</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Li, X]]
[[Category: Schmiege, P]]
[[Category: Schmiege, P]]
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[[Category: Li, X]]
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[[Category: Human trpml1]]
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[[Category: Membrane protein]]

Revision as of 07:19, 18 October 2017

cryo-EM of a lysosomal protein

5wj9, resolution 3.49Å

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