1ysv

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|PDB= 1ysv |SIZE=350|CAPTION= <scene name='initialview01'>1ysv</scene>
|PDB= 1ysv |SIZE=350|CAPTION= <scene name='initialview01'>1ysv</scene>
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|SITE=
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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|ACTIVITY=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ysv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysv OCA], [http://www.ebi.ac.uk/pdbsum/1ysv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ysv RCSB]</span>
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[[Category: structure]]
[[Category: structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:27:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:20:49 2008''

Revision as of 22:20, 30 March 2008

Image:1ysv.gif


PDB ID 1ysv

Drag the structure with the mouse to rotate
Ligands: , , ,
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Solution structure of the central region of the human GluR-B R/G pre-mRNA


Overview

Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2.

About this Structure

1YSV is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:15840813

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