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2ich

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Revision as of 08:27, 18 October 2017

CRYSTAL STRUCTURE OF A PUTATIVE ATTH (NE1406) FROM NITROSOMONAS EUROPAEA AT 2.00 A RESOLUTION

Structural highlights

2ich is a 2 chain structure with sequence from "bacterium_nitrosomonas"_lehmann_and_neumann_1899 "bacterium nitrosomonas" lehmann and neumann 1899. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
NonStd Res:
Gene:	NP_841447.1 ("Bacterium nitrosomonas" Lehmann and Neumann 1899)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The first structural representative of the domain of unknown function DUF2006 family, also known as Pfam family PF09410, comprises a lipocalin-like fold with domain duplication. The finding of the calycin signature in the N-terminal domain, combined with remote sequence similarity to two other protein families (PF07143 and PF08622) implicated in isoprenoid metabolism and the oxidative stress response, support an involvement in lipid metabolism. Clusters of conserved residues that interact with ligand mimetics suggest that the binding and regulation sites map to the N-terminal domain and to the interdomain interface, respectively.

Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism.,Chiu HJ, Bakolitsa C, Skerra A, Lomize A, Carlton D, Miller MD, Krishna SS, Abdubek P, Astakhova T, Axelrod HL, Clayton T, Deller MC, Duan L, Feuerhelm J, Grant JC, Grzechnik SK, Han GW, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kozbial P, Kumar A, Marciano D, McMullan D, Morse AT, Nigoghossian E, Okach L, Paulsen J, Reyes R, Rife CL, van den Bedem H, Weekes D, Xu Q, Hodgson KO, Wooley J, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt, 10):1153-9. Epub 2009 Dec 8. PMID:20944205^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Chiu HJ, Bakolitsa C, Skerra A, Lomize A, Carlton D, Miller MD, Krishna SS, Abdubek P, Astakhova T, Axelrod HL, Clayton T, Deller MC, Duan L, Feuerhelm J, Grant JC, Grzechnik SK, Han GW, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kozbial P, Kumar A, Marciano D, McMullan D, Morse AT, Nigoghossian E, Okach L, Paulsen J, Reyes R, Rife CL, van den Bedem H, Weekes D, Xu Q, Hodgson KO, Wooley J, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA. Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt, 10):1153-9. Epub 2009 Dec 8. PMID:20944205 doi:10.1107/S1744309109037749

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ich"

Categories: Bacterium nitrosomonas lehmann and neumann 1899 | Structural genomic | Jcsg | Lipid binding protein | PSI, Protein structure initiative

@@ Line 1: / Line 1: @@
 ==CRYSTAL STRUCTURE OF A PUTATIVE ATTH (NE1406) FROM NITROSOMONAS EUROPAEA AT 2.00 A RESOLUTION==
 <StructureSection load='2ich' size='340' side='right' caption='[[2ich]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
@@ Line 6: / Line 7: @@
 <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NP_841447.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=915 "Bacterium nitrosomonas" Lehmann and Neumann 1899])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ich FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ich OCA], [http://pdbe.org/2ich PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ich RCSB], [http://www.ebi.ac.uk/pdbsum/2ich PDBsum], [http://www.topsan.org/Proteins/JCSG/2ich TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ich FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ich OCA], [http://pdbe.org/2ich PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ich RCSB], [http://www.ebi.ac.uk/pdbsum/2ich PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ich ProSAT], [http://www.topsan.org/Proteins/JCSG/2ich TOPSAN]</span></td></tr>
 </table>
 == Evolutionary Conservation ==

2ich

From Proteopedia

Revision as of 08:27, 18 October 2017

CRYSTAL STRUCTURE OF A PUTATIVE ATTH (NE1406) FROM NITROSOMONAS EUROPAEA AT 2.00 A RESOLUTION

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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