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1ln6

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Revision as of 10:32, 18 October 2017

STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)

Structural highlights

1ln6 is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	1eds, 1edv, 1edw, 1fdf, 1jfp
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The structural changes that accompany activation of a G-protein coupled receptor (GPCR) are not well understood. To better understand the activation of rhodopsin, the GPCR responsible for visual transduction, we report studies on the three-dimensional structure for the activated state of this receptor, metarhodopsin II. Differences between the three-dimensional structure of ground state rhodopsin and metarhodopsin II, particularly in the cytoplasmic face of the receptor, suggest how the receptor is activated to couple with transducin. In particular, activation opens a groove on the surface of the receptor that could bind the N-terminal helix of the G protein, transducin alpha.

Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin.,Choi G, Landin J, Galan JF, Birge RR, Albert AD, Yeagle PL Biochemistry. 2002 Jun 11;41(23):7318-24. PMID:12044163^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Nakamichi H, Okada T. Local peptide movement in the photoreaction intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12729-34. Epub 2006 Aug 14. PMID:16908857
↑ Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607
↑ Choi G, Landin J, Galan JF, Birge RR, Albert AD, Yeagle PL. Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin. Biochemistry. 2002 Jun 11;41(23):7318-24. PMID:12044163

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ln6"

@@ Line 1: / Line 1: @@
 ==STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)==
 <StructureSection load='1ln6' size='340' side='right' caption='[[1ln6]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
@@ Line 5: / Line 6: @@
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1eds|1eds]], [[1edv|1edv]], [[1edw|1edw]], [[1fdf|1fdf]], [[1jfp|1jfp]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ln6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ln6 OCA], [http://pdbe.org/1ln6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ln6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ln6 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ln6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ln6 OCA], [http://pdbe.org/1ln6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ln6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ln6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ln6 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 17: / Line 18: @@
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ln6 ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 28: / Line 29: @@
 </div>
 <div class="pdbe-citations 1ln6" style="background-color:#fffaf0;"></div>
-==See Also==
-*[[Rhodopsin|Rhodopsin]]
 == References ==
 <references/>

1ln6

From Proteopedia

Revision as of 10:32, 18 October 2017

STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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