BRCA

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Revision as of 21:11, 18 October 2017

spinqualitylabelsall models Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code 3coj) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function BRCA1 and BRCA2 or breast cancer type 1 susceptibility protein are tumor suppressors which help repair damaged DNA. For more details see: RING Finger Domain of BRCA1 and BARD1 Heterodimer. Mutations in BRCA1/BARD1 RING-domain heterodimer. Mutations in Brca1 BRCT Domains. Disease Mutations in BRAC1 and BRAC2 are associated with increased risk of breast cancer, ovarian cancer and to a lesser extent with other cancers[1]. Structural highlights The . These domains contain most of the mutations seen in BRCA1[2]. .

3D structures of BRCA1

Updated on 18-October-2017

4ofb, 4y18, 4y2g, 4u4a, 4jlu, 4ifi, 4igk, 3k0h, 3k0k, 3coj, 1y98, 1t15, 1t29, 1t2v - hBRCA1 BRCT1 domain + peptide inhibitor - human
3pxa, 3pxb, 3pxc, 3pxd, 3pxe, 3k15, 3k16 - hBRCA1 BRCT1 domain (mutant) + peptide inhibitor
1jnx - hBRCA1 BRCT domain
2ing, 1t2u, 1n5o - hBRCA1 BRCT1 domain (mutant)
1oqa - hBRCA1 BRCT-C domain - NMR
1l0b - BRCA1 BRCT domain - rat
2n9e - hBRCA1 SUMO-interacting motif + small ubiquitin-related modifier - NMR
4mkf, 4mkg - hBRCA1 SUMO-interacting motif - NMR
1jm7 - hBRCA1 Ring domain + BARD1 ring domian - NMR

References

1. ↑ Petrucelli N, Daly MB, Pal T. BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer PMID:20301425
2. ↑ Shen Y, Tong L. Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1. Biochemistry. 2008 May 27;47(21):5767-73. Epub 2008 May 2. PMID:18452305 doi:10.1021/bi800314m