Haptoglobin receptor

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Revision as of 21:25, 19 October 2017

spinqualitylabelsall models IsdH NEAT-3 domain (magenta) complex with heme-containing hemoglobin subunits α (green) and β (deepskyblue) (PDB code 3szk) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Haptoglobin receptor (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins. IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex. IsdH contains multiple NEAT (Near Transporter) domains which bind proteins and heme[1]. For more details see Molecular Playground/Hemoglobin-Haptoglobin Complex. . (PDB code 3szk) . .

3D Structures of haptoglobin receptor

Updated on 19-October-2017

References

1. ↑ Vanhollebeke B, De Muylder G, Nielsen MJ, Pays A, Tebabi P, Dieu M, Raes M, Moestrup SK, Pays E. A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans. Science. 2008 May 2;320(5876):677-81. doi: 10.1126/science.1156296. PMID:18451305 doi:http://dx.doi.org/10.1126/science.1156296