Haptoglobin receptor
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='400' side='right' caption='IsdH NEAT-3 domain (magenta) complex with heme-containing hemoglobin subunits α (green) and β (deepskyblue) (PDB code [[3szk]])' scene='70/706235/Cv/1' pspeed='8'> |
== Function == | == Function == | ||
'''Haptoglobin receptor''' (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins. IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex. IsdH contains multiple '''NEAT''' (Near Transporter) domains which bind proteins and heme<ref>PMID:18451305</ref>. For more details see [[Molecular Playground/Hemoglobin-Haptoglobin Complex]]. | '''Haptoglobin receptor''' (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins. IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex. IsdH contains multiple '''NEAT''' (Near Transporter) domains which bind proteins and heme<ref>PMID:18451305</ref>. For more details see [[Molecular Playground/Hemoglobin-Haptoglobin Complex]]. | ||
Revision as of 06:51, 20 October 2017
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3D Structures of haptoglobin receptor
Updated on 20-October-2017
References
- ↑ Vanhollebeke B, De Muylder G, Nielsen MJ, Pays A, Tebabi P, Dieu M, Raes M, Moestrup SK, Pays E. A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans. Science. 2008 May 2;320(5876):677-81. doi: 10.1126/science.1156296. PMID:18451305 doi:http://dx.doi.org/10.1126/science.1156296
