Diacylglycerol kinase

From Proteopedia

Revision as of 10:00, 20 October 2017

spinqualitylabelsall models Diacylglycerol kinase DkgB complex with ADP and Mg+2 ion (green) (PDB code 2qv7) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Diacylglycerol kinase (DAGK) catalyzes the conversion of diacylglycerol to phosphaditic acid using ATP as energy source. DAGK is active upon receptor activation of the phosphoinositide pathway.[1] The bacterial DAGK contains 2 families: DgkA and DgkB. Relevance DAGK is tested as a possible therapeutic target for neuronal diseases. Structural highlights In DAGK DgkB the is found at the interface between the 2 domains of the structure. [2]

3D Structures of diacylglycerol kinase

Updated on 20-October-2017

References

1. ↑ Merida I, Avila-Flores A, Merino E. Diacylglycerol kinases: at the hub of cell signalling. Biochem J. 2008 Jan 1;409(1):1-18. PMID:18062770 doi:http://dx.doi.org/10.1042/BJ20071040
2. ↑ Miller DJ, Jerga A, Rock CO, White SW. Analysis of the Staphylococcus aureus DgkB structure reveals a common catalytic mechanism for the soluble diacylglycerol kinases. Structure. 2008 Jul;16(7):1036-46. PMID:18611377 doi:http://dx.doi.org/10.1016/j.str.2008.03.019