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5giy

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'''Unreleased structure'''
 
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The entry 5giy is ON HOLD until Jun 25 2018
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==HSA-Palmitic acid-[RuCl5(ind)]2-==
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<StructureSection load='5giy' size='340' side='right' caption='[[5giy]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
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Authors: Yang, F., Wang, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5giy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GIY FirstGlance]. <br>
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Description: HSA-Palmitic acid-[RuCl5(ind)]2-
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7GE:pentakis(chloranyl)-(1~{H}-indazol-2-ium-2-yl)ruthenium(1-)'>7GE</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5giy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5giy OCA], [http://pdbe.org/5giy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5giy RCSB], [http://www.ebi.ac.uk/pdbsum/5giy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5giy ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Wang, T]]
[[Category: Yang, F]]
[[Category: Yang, F]]
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[[Category: Wang, T]]
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[[Category: Anticancer activity]]
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[[Category: Drug delivery system]]
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[[Category: Human serum albumin]]
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[[Category: Interactions of protein-ligand]]
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[[Category: Peptide binding protein]]
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[[Category: Ruthenium-based drug]]

Revision as of 15:58, 20 October 2017

HSA-Palmitic acid-[RuCl5(ind)]2-

5giy, resolution 2.54Å

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