1z24
From Proteopedia
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|PDB= 1z24 |SIZE=350|CAPTION= <scene name='initialview01'>1z24</scene>, resolution 2.6Å | |PDB= 1z24 |SIZE=350|CAPTION= <scene name='initialview01'>1z24</scene>, resolution 2.6Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=BLV:BILIVERDIN IX GAMMA CHROMOPHORE'>BLV</scene> | + | |LIGAND= <scene name='pdbligand=BLV:BILIVERDIN+IX+GAMMA+CHROMOPHORE'>BLV</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z24 OCA], [http://www.ebi.ac.uk/pdbsum/1z24 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z24 RCSB]</span> | ||
}} | }} | ||
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[[Category: Rayment, I.]] | [[Category: Rayment, I.]] | ||
[[Category: Rypniewski, W R.]] | [[Category: Rypniewski, W R.]] | ||
| - | [[Category: BLV]] | ||
[[Category: blue biliprotein]] | [[Category: blue biliprotein]] | ||
[[Category: chromophore binding.]] | [[Category: chromophore binding.]] | ||
[[Category: ins-a]] | [[Category: ins-a]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:27:59 2008'' |
Revision as of 22:28, 30 March 2008
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| , resolution 2.6Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution.
Overview
Insecticyanin, a blue biliprotein isolated from the tobacco hornworm Manduca sexta L., is involved in insect camouflage. Its three-dimensional structure has now been solved to 2.6 A resolution using the techniques of multiple isomorphous replacement, non-crystallographic symmetry averaging about a local 2-fold rotation axis and solvent flattening. All 189 amino acids have been fitted to the electron density map. The map clearly shows that insecticyanin is a tetramer with one of its molecular 2-fold axes coincident to a crystallographic dyad. The individual subunits have overall dimensions of 44 A X 37 A X 40 A and consist primarily of an eight-stranded anti-parallel beta-barrel flanked on one side by a 4.5-turn alpha-helix. Interestingly the overall three-dimensional fold of the insecticyanin subunit shows remarkable similarity to the structural motifs of bovine beta-lactoglobulin and the human serum retinol-binding protein. The electron density attributable to the chromophore is unambiguous and shows that it is indeed the gamma-isomer of biliverdin. The biliverdin lies towards the open end of the beta-barrel with its two propionate side chains pointing towards the solvent and it adopts a rather folded conformation, much like a heme.
About this Structure
1Z24 is a Single protein structure of sequence from Manduca sexta. Full crystallographic information is available from OCA.
Reference
The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution., Holden HM, Rypniewski WR, Law JH, Rayment I, EMBO J. 1987 Jun;6(6):1565-70. PMID:3608987
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