1oan

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[[Category: membrane fusion]]
[[Category: membrane fusion]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:19:02 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 16:48:27 2007''

Revision as of 14:43, 5 November 2007

Image:1oan.gif

1oan, resolution 2.75Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN

Overview

Dengue virus is an emerging global health threat. Its major envelope, glycoprotein, E, mediates viral attachment and entry by membrane fusion. A, crystal structure of the soluble ectodomain of E from dengue virus type 2, reveals a hydrophobic pocket lined by residues that influence the pH, threshold for fusion. The pocket, which accepts a hydrophobic ligand, opens and closes through a conformational shift in a beta-hairpin at the, interface between two domains. These features point to a structural, pathway for the fusion-activating transition and suggest a strategy for, finding small-molecule inhibitors of dengue and other flaviviruses.

About this Structure

1OAN is a Single protein structure of sequence from Dengue virus type 3 with NAG and NA as ligands. Structure known Active Site: AC1. Full crystallographic information is available from OCA.

Reference

A ligand-binding pocket in the dengue virus envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91. Epub 2003 May 20. PMID:12759475

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