Neurophysin

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spinqualitylabelsall models Neurophysin-2 (green and cyan) complex with oxytocin (magenta and salmon) (PDB code 1npo) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Neurophysins are carrier proteins which transport hormones from the hypothalamus to the posterior pituitary gland[1]. Neurophysin-1 transports oxytocin. Neurophysin-2 transports vasopressin. Oxytocin is used to start labor and increase its speed. Vasopressin functions to retain water in the body and to constrict blood vessels. Disease Mutations in neurophysin-2 are associated with familial diabetes[2]. Structural highlights .

3D Structures of neurophysin

Updated on 20-October-2017

References

1. ↑ Acher R, Chauvet J. Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors. Biochimie. 1988 Sep;70(9):1197-207. PMID:3147712
2. ↑ Nagasaki H, Ito M, Yuasa H, Saito H, Fukase M, Hamada K, Ishikawa E, Katakami H, Oiso Y. Two novel mutations in the coding region for neurophysin-II associated with familial central diabetes insipidus. J Clin Endocrinol Metab. 1995 Apr;80(4):1352-6. PMID:7714110 doi:http://dx.doi.org/10.1210/jcem.80.4.7714110