Nitrate reductase

From Proteopedia

Revision as of 18:14, 20 October 2017

spinqualitylabelsall models Bacterial periplasmic dissimilatory nitrate reductase containing Fe4S4 cluster with Mo, NO3- and molybdepterin guanine nucleotide (PDB entry 2jiq) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Nitrate reductase (NR) catalyzes the reduction of NO3 to NO2 using NADPH[1]. NR active site contains Mo atom. Four types of NR are known: eukaryotic assimilatory NR bacterial cytoplasmic assimilatory (NAC) bacterial membrane-bound respiratory (NAR) bacterial periplasmic dissimilatory (NAP). The cofactors of NR are Molybdopterin (MPT) in eukaryotic NR and bis-Molybdopterin guanine dinucleotide (MGD) in bacterial NR. Structural highlights . NAP active site includes a . The [2].

3D structures of nitrate reductase

Updated on 20-October-2017

References

1. ↑ NICHOLAS DJ, NASON A. Molybdenum and nitrate reductase. II. Molybdenum as a constituent of nitrate reductase. J Biol Chem. 1954 Mar;207(1):353-60. PMID:13152110
2. ↑ Najmudin S, Gonzalez PJ, Trincao J, Coelho C, Mukhopadhyay A, Cerqueira NM, Romao CC, Moura I, Moura JJ, Brondino CD, Romao MJ. Periplasmic nitrate reductase revisited: a sulfur atom completes the sixth coordination of the catalytic molybdenum. J Biol Inorg Chem. 2008 Mar 8;. PMID:18327621 doi:10.1007/s00775-008-0359-6