1z3u
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1z3u |SIZE=350|CAPTION= <scene name='initialview01'>1z3u</scene>, resolution 2.25Å | |PDB= 1z3u |SIZE=350|CAPTION= <scene name='initialview01'>1z3u</scene>, resolution 2.25Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1z3s|1Z3S]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3u OCA], [http://www.ebi.ac.uk/pdbsum/1z3u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z3u RCSB]</span> | ||
}} | }} | ||
| Line 25: | Line 28: | ||
[[Category: Nikolov, D B.]] | [[Category: Nikolov, D B.]] | ||
[[Category: Tzvetkova, D.]] | [[Category: Tzvetkova, D.]] | ||
| - | [[Category: CA]] | ||
[[Category: angiogenesis]] | [[Category: angiogenesis]] | ||
[[Category: extracellular ligand]] | [[Category: extracellular ligand]] | ||
[[Category: tie2 binding]] | [[Category: tie2 binding]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:28:41 2008'' |
Revision as of 22:28, 30 March 2008
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| , resolution 2.25Å | |||||||
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| Ligands: | |||||||
| Related: | 1Z3S
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the Angiopoietin-2 Recptor Binding Domain and Identification of Surfaces Involved in Tie2 Recognition
Overview
The angiopoietins comprise a small class of secreted glycoproteins that play crucial roles in the maturation and maintenance of the mammalian vascular and lymphatic systems. They exert their effects through a member of the tyrosine kinase receptor family, Tie2. Angiopoietin/Tie2 signaling is unique among tyrosine kinase receptor-ligand systems in that distinct angiopoietin ligands, although highly homologous, can function as agonists or antagonists in a context-dependent manner. In an effort to understand this molecular dichotomy, we have crystallized and determined the 2.4 A crystal structure of the Angiopoietin-2 (Ang2) receptor binding region. The structure reveals a fibrinogen fold with a unique C-terminal P domain. Conservation analysis and structure-based mutagenesis identify a groove on the Ang2 molecular surface that mediates receptor recognition.
About this Structure
1Z3U is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition., Barton WA, Tzvetkova D, Nikolov DB, Structure. 2005 May;13(5):825-32. PMID:15893672
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