1z6o
From Proteopedia
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|PDB= 1z6o |SIZE=350|CAPTION= <scene name='initialview01'>1z6o</scene>, resolution 1.91Å | |PDB= 1z6o |SIZE=350|CAPTION= <scene name='initialview01'>1z6o</scene>, resolution 1.91Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z6o OCA], [http://www.ebi.ac.uk/pdbsum/1z6o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z6o RCSB]</span> | ||
}} | }} | ||
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[[Category: Hamburger, Z A.]] | [[Category: Hamburger, Z A.]] | ||
[[Category: Jr., A P.West.]] | [[Category: Jr., A P.West.]] | ||
| - | + | [[Category: metal binding protein,iron storage]] | |
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| - | [[Category: metal binding protein]] | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:30:01 2008'' |
Revision as of 22:30, 30 March 2008
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| , resolution 1.91Å | |||||||
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| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Trichoplusia ni secreted ferritin
Overview
Ferritins are iron storage proteins made of 24 subunits forming a hollow spherical shell. Vertebrate ferritins contain varying ratios of heavy (H) and light (L) chains; however, known ferritin structures include only one type of chain and have octahedral symmetry. Here, we report the 1.9A structure of a secreted insect ferritin from Trichoplusia ni, which reveals equal numbers of H and L chains arranged with tetrahedral symmetry. The H/L-chain interface includes complementary features responsible for ordered assembly of the subunits. The H chain contains a ferroxidase active site resembling that of vertebrate H chains with an endogenous, bound iron atom. The L chain lacks the residues that form a putative iron core nucleation site in vertebrate L chains. Instead, a possible nucleation site is observed at the L chain 3-fold pore. The structure also reveals inter- and intrasubunit disulfide bonds, mostly in the extended N-terminal regions unique to insect ferritins. The symmetrical arrangement of H and L chains and the disulfide crosslinks reflect adaptations of insect ferritin to its role as a secreted protein.
About this Structure
1Z6O is a Protein complex structure of sequences from Trichoplusia ni. Full crystallographic information is available from OCA.
Reference
Crystal structure of a secreted insect ferritin reveals a symmetrical arrangement of heavy and light chains., Hamburger AE, West AP Jr, Hamburger ZA, Hamburger P, Bjorkman PJ, J Mol Biol. 2005 Jun 10;349(3):558-69. Epub 2005 Apr 12. PMID:15896348
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