1z6q
From Proteopedia
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|PDB= 1z6q |SIZE=350|CAPTION= <scene name='initialview01'>1z6q</scene>, resolution 2.03Å | |PDB= 1z6q |SIZE=350|CAPTION= <scene name='initialview01'>1z6q</scene>, resolution 2.03Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=195:4-{2,4-BIS[(3-NITROBENZOYL)AMINO]PHENOXY}PHTHALIC ACID'>195</scene> | + | |LIGAND= <scene name='pdbligand=195:4-{2,4-BIS[(3-NITROBENZOYL)AMINO]PHENOXY}PHTHALIC+ACID'>195</scene>, <scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1z6p|1Z6P]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z6q OCA], [http://www.ebi.ac.uk/pdbsum/1z6q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z6q RCSB]</span> | ||
}} | }} | ||
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[[Category: Kristiansen, M.]] | [[Category: Kristiansen, M.]] | ||
[[Category: Westergaard, N.]] | [[Category: Westergaard, N.]] | ||
| - | [[Category: | + | [[Category: allosteric]] |
| - | [[Category: glycogen metabolism | + | [[Category: glycogen metabolism]] |
| + | [[Category: glycogen phosphorylase b]] | ||
| + | [[Category: inhibition]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:30:14 2008'' |
Revision as of 22:30, 30 March 2008
| |||||||
| , resolution 2.03Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Activity: | Phosphorylase, with EC number 2.4.1.1 | ||||||
| Related: | 1Z6P
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Glycogen phosphorylase with inhibitor in the AMP site
Overview
Inhibition of glycogen phosphorylase (GP) has attracted considerable attention during the last five to 10 years as a means of treating the elevated hepatic glucose production seen in patients with type 2 diabetes. Several different GP inhibitors binding to various binding sites of the GP enzyme have been reported in the literature. In this paper we report on a novel class of compounds that have been identified as potent GP inhibitors. Their synthesis, mode of binding to the allosteric AMP site as well as in vitro data on GP inhibition are shown. The most potent inhibitor was found to be 4-[2,4-bis-(3-nitrobenzoylamino)phenoxy]phthalic acid (4j) with an IC(50) value of 74 nM. This compound together with a closely related analogue was further characterized by enzyme kinetics and in primary rat hepatocytes.
About this Structure
1Z6Q is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.
Reference
Identification, synthesis, and characterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site., Kristiansen M, Andersen B, Iversen LF, Westergaard N, J Med Chem. 2004 Jul 1;47(14):3537-45. PMID:15214781
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