5j7j
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR Derived Structure of Ca2+ Calmodulin bound to Phosphorylated PSD-95== | |
| - | + | <StructureSection load='5j7j' size='340' side='right' caption='[[5j7j]], [[NMR_Ensembles_of_Models | 4 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5j7j]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J7J FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mes|2mes]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j7j OCA], [http://pdbe.org/5j7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j7j RCSB], [http://www.ebi.ac.uk/pdbsum/5j7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j7j ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CALM_XENLA CALM_XENLA]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. [[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ames, J B]] | ||
| + | [[Category: Anderson, D E]] | ||
| + | [[Category: Turner, M L]] | ||
| + | [[Category: Calmodulin]] | ||
| + | [[Category: Metal binding protein]] | ||
| + | [[Category: Phosphorylated]] | ||
| + | [[Category: Psd-95]] | ||
| + | [[Category: Voltage-gated channel]] | ||
Revision as of 07:10, 25 October 2017
NMR Derived Structure of Ca2+ Calmodulin bound to Phosphorylated PSD-95
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