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5lxo
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Coiled-coil protein== | |
| - | + | <StructureSection load='5lxo' size='340' side='right' caption='[[5lxo]], [[Resolution|resolution]] 2.18Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lxo]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LXO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxo OCA], [http://pdbe.org/5lxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lxo RCSB], [http://www.ebi.ac.uk/pdbsum/5lxo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TACC3_HUMAN TACC3_HUMAN]] Gliosarcoma;Giant cell glioblastoma. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TACC3_HUMAN TACC3_HUMAN]] Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).[UniProtKB:Q9JJ11]<ref>PMID:14767476</ref> <ref>PMID:21297582</ref> <ref>PMID:23532825</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bunney, T D]] | ||
| + | [[Category: Katan, M]] | ||
| + | [[Category: Thiyagarajan, N]] | ||
| + | [[Category: Cancer]] | ||
| + | [[Category: Coiled-coil]] | ||
| + | [[Category: Fgfr]] | ||
| + | [[Category: Fgfr fusion]] | ||
| + | [[Category: Fusion]] | ||
| + | [[Category: Growth factor]] | ||
| + | [[Category: Helix]] | ||
| + | [[Category: Parallel helix]] | ||
| + | [[Category: Structural protein]] | ||
| + | [[Category: Tacc3]] | ||
Revision as of 07:11, 25 October 2017
Coiled-coil protein
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Categories: Bunney, T D | Katan, M | Thiyagarajan, N | Cancer | Coiled-coil | Fgfr | Fgfr fusion | Fusion | Growth factor | Helix | Parallel helix | Structural protein | Tacc3
