5tn0
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Solution Structure of the N-terminal DNA-binding domain of the master biofilm-regulator SinR from Bacillus subtilis== | |
| - | + | <StructureSection load='5tn0' size='340' side='right' caption='[[5tn0]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5tn0]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TN0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TN0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tn2|5tn2]], [[5tmx|5tmx]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tn0 OCA], [http://pdbe.org/5tn0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tn0 RCSB], [http://www.ebi.ac.uk/pdbsum/5tn0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tn0 ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/SINR_BACSU SINR_BACSU]] Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swarm and a state in which bacteria assemble into multicellular communities. Acts with Hpr as a corepressor of epr expression. Also negatively regulates transcription of the lutABC operon, which is required for lactate utilization. Repressor activity is regulated by SinI.<ref>PMID:1898931</ref> <ref>PMID:7642487</ref> <ref>PMID:15661000</ref> <ref>PMID:16923912</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bobay, B G]] | ||
[[Category: Cavanagh, J]] | [[Category: Cavanagh, J]] | ||
| - | [[Category: Stowe, S | + | [[Category: Draughn, G L]] |
| - | [[Category: | + | [[Category: Stowe, S D]] |
| + | [[Category: Thompson, R J]] | ||
| + | [[Category: Biofilm formation]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 07:16, 25 October 2017
Solution Structure of the N-terminal DNA-binding domain of the master biofilm-regulator SinR from Bacillus subtilis
| |||||||||||
