5xof
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human paired immunoglobulin-like type 2 receptor alpha with synthesized glycopeptide I== | |
| - | + | <StructureSection load='5xof' size='340' side='right' caption='[[5xof]], [[Resolution|resolution]] 1.96Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5xof]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XOF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xof OCA], [http://pdbe.org/5xof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xof RCSB], [http://www.ebi.ac.uk/pdbsum/5xof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xof ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PILRA_HUMAN PILRA_HUMAN]] Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.<ref>PMID:10903717</ref> <ref>PMID:18358807</ref> <ref>PMID:21241660</ref> [[http://www.uniprot.org/uniprot/NOS3_HUMAN NOS3_HUMAN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.<ref>PMID:17264164</ref> Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.<ref>PMID:17264164</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Anada, M]] | ||
| + | [[Category: Arase, H]] | ||
| + | [[Category: Furukawa, A]] | ||
| + | [[Category: Hashimoto, S]] | ||
| + | [[Category: Hatori, N]] | ||
[[Category: Ishizuka, M]] | [[Category: Ishizuka, M]] | ||
[[Category: Kakita, K]] | [[Category: Kakita, K]] | ||
| - | [[Category: | + | [[Category: Kuroki, K]] |
| - | [[Category: | + | [[Category: Maeda, N]] |
| + | [[Category: Maenaka, K]] | ||
| + | [[Category: Matsunaga, H]] | ||
| + | [[Category: Nambu, H]] | ||
[[Category: Nomura, T]] | [[Category: Nomura, T]] | ||
[[Category: Ohsaka, F]] | [[Category: Ohsaka, F]] | ||
| + | [[Category: Ose, T]] | ||
| + | [[Category: Saitoh, T]] | ||
[[Category: Sakamoto, J]] | [[Category: Sakamoto, J]] | ||
| - | [[Category: Matsunaga, H]] | ||
| - | [[Category: Maeda, N]] | ||
| - | [[Category: Saitoh, T]] | ||
| - | [[Category: Kuroki, K]] | ||
| - | [[Category: Hashimoto, S]] | ||
| - | [[Category: Nambu, H]] | ||
| - | [[Category: Maenaka, K]] | ||
[[Category: Yamada, T]] | [[Category: Yamada, T]] | ||
| - | [[Category: | + | [[Category: Glycopeptide]] |
| - | [[Category: | + | [[Category: Immune receptor]] |
| - | [[Category: | + | [[Category: Immune system]] |
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Viral entry inhibitor]] | ||
Revision as of 07:19, 25 October 2017
Crystal structure of human paired immunoglobulin-like type 2 receptor alpha with synthesized glycopeptide I
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Categories: Anada, M | Arase, H | Furukawa, A | Hashimoto, S | Hatori, N | Ishizuka, M | Kakita, K | Kuroki, K | Maeda, N | Maenaka, K | Matsunaga, H | Nambu, H | Nomura, T | Ohsaka, F | Ose, T | Saitoh, T | Sakamoto, J | Yamada, T | Glycopeptide | Immune receptor | Immune system | Membrane protein | Viral entry inhibitor
