3biy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
 +
==Crystal structure of p300 histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA==
==Crystal structure of p300 histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA==
<StructureSection load='3biy' size='340' side='right' caption='[[3biy]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3biy' size='340' side='right' caption='[[3biy]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3biy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. The February 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Enhanceosome'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_2 10.2210/rcsb_pdb/mom_2010_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BIY FirstGlance]. <br>
<table><tr><td colspan='2'>[[3biy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. The February 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Enhanceosome'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_2 10.2210/rcsb_pdb/mom_2010_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BIY FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=01K:[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL+(3R,20R)-20-CARBAMOYL-3-HYDROXY-2,2-DIMETHYL-4,8,14,22-TETRAOXO-12-THIA-5,9,15,21-TETRAAZATRICOS-1-YL+DIHYDROGEN+DIPHOSPHATE'>01K</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=01K:[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl+(3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl+dihydrogen+diphosphate'>01K</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EP300, P300 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EP300, P300 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3biy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3biy OCA], [http://pdbe.org/3biy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3biy RCSB], [http://www.ebi.ac.uk/pdbsum/3biy PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3biy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3biy OCA], [http://pdbe.org/3biy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3biy RCSB], [http://www.ebi.ac.uk/pdbsum/3biy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3biy ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
Line 31: Line 32:
</div>
</div>
<div class="pdbe-citations 3biy" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3biy" style="background-color:#fffaf0;"></div>
- 
-
==See Also==
 
-
*[[Histone acetyltransferase|Histone acetyltransferase]]
 
== References ==
== References ==
<references/>
<references/>

Revision as of 08:04, 25 October 2017

Crystal structure of p300 histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA

3biy, resolution 1.70Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3biy"
Personal tools