1mgp

From Proteopedia

(Difference between revisions)

Revision as of 10:10, 25 October 2017

Hypothetical protein TM841 from Thermotoga maritima reveals fatty acid binding function

Structural highlights

1mgp is a 1 chain structure with sequence from Atcc 43589. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

[Y1468_THEMA] Binds long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

We determined the three-dimensional (3D) crystal structure of protein TM841, a protein product from a hypothetical open-reading frame in the genome of the hyperthermophile bacterium Thermotoga maritima, to 2.0 A resolution. The protein belongs to a large protein family, DegV or COG1307 of unknown function. The 35 kDa protein consists of two separate domains, with low-level structural resemblance to domains from other proteins with known 3D structures. These structural homologies, however, provided no clues for the function of TM841. But the electron density maps revealed clear density for a bound fatty-acid molecule in a pocket between the two protein domains. The structure indicates that TM841 has the molecular function of fatty-acid binding and may play a role in the cellular functions of fatty acid transport or metabolism.

Crystal structure of a hypothetical protein, TM841 of Thermotoga maritima, reveals its function as a fatty acid-binding protein.,Schulze-Gahmen U, Pelaschier J, Yokota H, Kim R, Kim SH Proteins. 2003 Mar 1;50(4):526-30. PMID:12577257^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Schulze-Gahmen U, Pelaschier J, Yokota H, Kim R, Kim SH. Crystal structure of a hypothetical protein, TM841 of Thermotoga maritima, reveals its function as a fatty acid-binding protein. Proteins. 2003 Mar 1;50(4):526-30. PMID:12577257 doi:10.1002/prot.10305

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mgp"

@@ Line 1: / Line 1: @@
 ==Hypothetical protein TM841 from Thermotoga maritima reveals fatty acid binding function==
 <StructureSection load='1mgp' size='340' side='right' caption='[[1mgp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
@@ Line 5: / Line 6: @@
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
 <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mgp OCA], [http://pdbe.org/1mgp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mgp RCSB], [http://www.ebi.ac.uk/pdbsum/1mgp PDBsum], [http://www.topsan.org/Proteins/BSGC/1mgp TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mgp OCA], [http://pdbe.org/1mgp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mgp RCSB], [http://www.ebi.ac.uk/pdbsum/1mgp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mgp ProSAT], [http://www.topsan.org/Proteins/BSGC/1mgp TOPSAN]</span></td></tr>
 </table>
 == Function ==
@@ Line 17: / Line 18: @@
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mgp ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">

1mgp

From Proteopedia

Revision as of 10:10, 25 October 2017

Hypothetical protein TM841 from Thermotoga maritima reveals fatty acid binding function

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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