1zig

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|PDB= 1zig |SIZE=350|CAPTION= <scene name='initialview01'>1zig</scene>
|PDB= 1zig |SIZE=350|CAPTION= <scene name='initialview01'>1zig</scene>
|SITE=
|SITE=
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|LIGAND=
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=[[1zif|1ZIF]], [[1zih|1ZIH]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zig OCA], [http://www.ebi.ac.uk/pdbsum/1zig PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zig RCSB]</span>
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}}
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[[Category: tetraloop]]
[[Category: tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:35:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:37:03 2008''

Revision as of 22:37, 30 March 2008

Image:1zig.gif


PDB ID 1zig

Drag the structure with the mouse to rotate
Ligands: , , ,
Related: 1ZIF, 1ZIH


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



GAGA RNA TETRALOOP, NMR, 10 STRUCTURES


Overview

RNA hairpin loops containing a GNRA consensus sequence are the most frequently occurring hairpins in a variety of prokaryotic and eukaryotic RNAs. These tetraloops play important functional roles in RNA folding, in RNA-RNA tertiary interactions and as protein binding sites. Homo and heteronuclear NMR spectroscopy have been used to determine the structures of the most abundant members of the GNRA tetraloop family: the GAGA, GCAA and GAAA loops closed by a C-G base pair. Analysis of the structures of these three hairpin loops reveals a network of heterogeneous hydrogen bonds. The loops contain a G-A base pair, a G base-phosphate hydrogen bond and several 2' OH-base hydrogen bonds. These intramolecular interactions and the extensive base stacking in the loop help explain the high thermodynamic stability and give insight into the diverse biological roles of the GNRA RNA hairpins.

About this Structure

1ZIG is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

A network of heterogeneous hydrogen bonds in GNRA tetraloops., Jucker FM, Heus HA, Yip PF, Moors EH, Pardi A, J Mol Biol. 1996 Dec 20;264(5):968-80. PMID:9000624

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