1od8

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[[Category: xylanase]]
[[Category: xylanase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:50:32 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 16:50:32 2007''

Revision as of 14:45, 5 November 2007

Image:1od8.gif

1od8, resolution 1.05Å

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XYLANASE XYN10A FROM STREPTOMYCES LIVIDANS IN COMPLEX WITH XYLOBIO-ISOFAGOMINE LACTAM

Overview

The atomic-resolution structure of a xylobiose-derived isofagomine lactam, in complex with the xylanase Xyn10A from Streptomyces lividans reveals, that the lactam is bound to the enzyme as the amide tautomer, with, "reversed" protonation-states for nucleophile and acid-base.

About this Structure

1OD8 is a Single protein structure of sequence from Streptomyces lividans with XYP, NA, XDL and IMD as ligands. Active as Endo-1,4-beta-xylanase, with EC number 3.2.1.8 Structure known Active Site: AC1. Full crystallographic information is available from OCA.

Reference

A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer., Gloster T, Williams SJ, Tarling CA, Roberts S, Dupont C, Jodoin P, Shareck F, Withers SG, Davies GJ, Chem Commun (Camb). 2003 Apr 21;(8):944-5. PMID:12744311

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