1zlc
From Proteopedia
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|PDB= 1zlc |SIZE=350|CAPTION= <scene name='initialview01'>1zlc</scene> | |PDB= 1zlc |SIZE=350|CAPTION= <scene name='initialview01'>1zlc</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | + | |LIGAND= <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zlc OCA], [http://www.ebi.ac.uk/pdbsum/1zlc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zlc RCSB]</span> | ||
}} | }} | ||
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[[Category: McIntosh, J M.]] | [[Category: McIntosh, J M.]] | ||
[[Category: Olivera, B M.]] | [[Category: Olivera, B M.]] | ||
| - | [[Category: NH2]] | ||
[[Category: alpha-helix]] | [[Category: alpha-helix]] | ||
[[Category: beta-turn]] | [[Category: beta-turn]] | ||
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[[Category: two disulfide bond]] | [[Category: two disulfide bond]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:38:13 2008'' |
Revision as of 22:38, 30 March 2008
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Conformation of alpha-conotoxin PIA
Overview
alpha-Conotoxin PIA is a novel nicotinic acetylcholine receptor (nAChR) antagonist isolated from Conus purpurascens that targets nAChR subtypes containing alpha6 and alpha3 subunits. alpha-conotoxin PIA displays 75-fold higher affinity for rat alpha6/alpha3beta2beta3 nAChRs than for rat alpha3beta2 nAChRs. We have determined the three-dimensional structure of alpha-conotoxin PIA by nuclear magnetic resonance spectroscopy. The alpha-conotoxin PIA has an "omega-shaped" overall topology as other alpha4/7 subfamily conotoxins. Yet, unlike other neuronally targeted alpha4/7-conotoxins, its N-terminal tail Arg1-Asp2-Pro3 protrudes out of its main molecular body because Asp2-Pro3-Cys4-Cys5 forms a stable type I beta-turn. In addition, a kink introduced by Pro15 in the second loop of this toxin provides a distinct steric and electrostatic environment from those in alpha-conotoxins MII and GIC. By comparing the structure of alpha-conotoxin PIA with other functionally related alpha-conotoxins we suggest structural features in alpha-conotoxin PIA that may be associated with its unique receptor recognition profile.
About this Structure
1ZLC is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Solution structure of alpha-conotoxin PIA, a novel antagonist of alpha6 subunit containing nicotinic acetylcholine receptors., Chi SW, Lee SH, Kim DH, Kim JS, Olivera BM, McIntosh JM, Han KH, Biochem Biophys Res Commun. 2005 Dec 30;338(4):1990-7. Epub 2005 Nov 7. PMID:16289101
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