5h3m
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of human Gelsolin protein domain 1 at pH 5.0== | |
| - | + | <StructureSection load='5h3m' size='340' side='right' caption='[[5h3m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5h3m]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H3M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5h3n|5h3n]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h3m OCA], [http://pdbe.org/5h3m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h3m RCSB], [http://www.ebi.ac.uk/pdbsum/5h3m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h3m ProSAT]</span></td></tr> |
| - | [[Category: Fan, J | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN]] Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:[http://omim.org/entry/105120 105120]]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.<ref>PMID:2157434</ref> <ref>PMID:2153578</ref> <ref>PMID:2176481</ref> <ref>PMID:1338910</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN]] Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.<ref>PMID:20393563</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fan, J S]] | ||
[[Category: Yang, D]] | [[Category: Yang, D]] | ||
| + | [[Category: Gelsolin]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 06:24, 1 November 2017
Solution structure of human Gelsolin protein domain 1 at pH 5.0
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