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3hdz
From Proteopedia
(Difference between revisions)
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<StructureSection load='3hdz' size='340' side='right' caption='[[3hdz]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='3hdz' size='340' side='right' caption='[[3hdz]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3hdz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HDZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HDZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3hdz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HDZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HDZ FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD6:5-AMINO-1-BUTYL-7-PHENYL-1,6-NAPHTHYRIDIN-4(1H)-ONE'>PD6</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD6:5-AMINO-1-BUTYL-7-PHENYL-1,6-NAPHTHYRIDIN-4(1H)-ONE'>PD6</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2h40|2h40]], [[2h42|2h42]], [[2h44|2h44]], [[3bjc|3bjc]], [[1uho|1uho]], [[2chm|2chm]], [[3hc8|3hc8]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2h40|2h40]], [[2h42|2h42]], [[2h44|2h44]], [[3bjc|3bjc]], [[1uho|1uho]], [[2chm|2chm]], [[3hc8|3hc8]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hdz OCA], [http://pdbe.org/3hdz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hdz RCSB], [http://www.ebi.ac.uk/pdbsum/3hdz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hdz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hdz OCA], [http://pdbe.org/3hdz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hdz RCSB], [http://www.ebi.ac.uk/pdbsum/3hdz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hdz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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</div> | </div> | ||
<div class="pdbe-citations 3hdz" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3hdz" style="background-color:#fffaf0;"></div> | ||
| - | |||
| - | ==See Also== | ||
| - | *[[Phosphodiesterase|Phosphodiesterase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Brown, D G]] | [[Category: Brown, D G]] | ||
[[Category: Cubbage, J W]] | [[Category: Cubbage, J W]] | ||
Revision as of 07:30, 1 November 2017
Identification, Synthesis, and SAR of Amino Substituted Pyrido[3,2b]pryaziones as Potent and Selective PDE5 Inhibitors
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Categories: Human | Brown, D G | Cubbage, J W | Hughes, R O | Jacobsen, E J | Walker, J K | Alternative splicing | Camp | Cgmp | Cgmp-binding | Hydrolase | Inhibition | Magnesium | Metal-binding | Nucleotide-binding | Pde-5 | Pde5 | Phosphoprotein | Polymorphism allosteric enzyme | Zinc

