1zpi
From Proteopedia
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|PDB= 1zpi |SIZE=350|CAPTION= <scene name='initialview01'>1zpi</scene>, resolution 1.60Å | |PDB= 1zpi |SIZE=350|CAPTION= <scene name='initialview01'>1zpi</scene>, resolution 1.60Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SN9:8-METHOXY-1-METHYL-4-(4-(4-(1-METHYLPYRIDINIUM-4-YLAMINO)PHENYLCARBAMOYL)PHENYLAMINO)QUINOLINIUM'>SN9 | + | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SN9:8-METHOXY-1-METHYL-4-(4-(4-(1-METHYLPYRIDINIUM-4-YLAMINO)PHENYLCARBAMOYL)PHENYLAMINO)QUINOLINIUM'>SN9</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1zph|1ZPH]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zpi OCA], [http://www.ebi.ac.uk/pdbsum/1zpi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zpi RCSB]</span> | ||
}} | }} | ||
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[[Category: Guss, J M.]] | [[Category: Guss, J M.]] | ||
[[Category: Leong, C.]] | [[Category: Leong, C.]] | ||
| - | [[Category: MG]] | ||
| - | [[Category: SN9]] | ||
[[Category: b-dna]] | [[Category: b-dna]] | ||
[[Category: dodecamer]] | [[Category: dodecamer]] | ||
[[Category: minor groove binding complex]] | [[Category: minor groove binding complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:39:59 2008'' |
Revision as of 22:40, 30 March 2008
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| , resolution 1.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , , | ||||||
| Related: | 1ZPH
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8224 complexed with CGCGAATTCGCG
Overview
The structures of the complexes formed between two anticancer minor-groove-binding quinolinium quaternary salts and the dodecamer d(CGCGAATTCGCG)(2) have been refined to resolutions of 1.6 and 1.8 Angstrom. The complexes crystallized in space group P2(1)2(1)2(1) and the structures are isomorphous with previously solved dodecamer structures. The ligands both bind in the central AT region of the minor groove and although the crystallization conditions and structures of the ligands are very similar, they bind in opposing orientations. The structures are compared with two previously published structures of quinolinium quaternary salts, refined at 2.5 Angstrom resolution, complexed with d(CGCGAATTCGCG)(2) and an e(6)G-modified DNA.
About this Structure
1ZPI is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structures of two minor-groove-binding quinolinium quaternary salts complexed with d(CGCGAATTCGCG)(2) at 1.6 and 1.8 Angstrom resolution., Adams A, Leong C, Denny WA, Guss JM, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1348-53. Epub 2005, Sep 28. PMID:16204886
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