1zr4
From Proteopedia
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|PDB= 1zr4 |SIZE=350|CAPTION= <scene name='initialview01'>1zr4</scene>, resolution 3.40Å | |PDB= 1zr4 |SIZE=350|CAPTION= <scene name='initialview01'>1zr4</scene>, resolution 3.40Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1zr2|1ZR2]], [[1gdt|1GDT]], [[2rsl|2RSL]], [[1gdr|1GDR]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zr4 OCA], [http://www.ebi.ac.uk/pdbsum/1zr4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zr4 RCSB]</span> | ||
}} | }} | ||
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[[Category: site-specific]] | [[Category: site-specific]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:40:36 2008'' |
Revision as of 22:40, 30 March 2008
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| , resolution 3.40Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Related: | 1ZR2, 1GDT, 2RSL, 1GDR
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of a Synaptic gamma-delta Resolvase Tetramer Covalently linked to two Cleaved DNAs
Overview
The structure of a synaptic intermediate of the site-specific recombinase gammadelta resolvase covalently linked through Ser10 to two cleaved duplex DNAs has been determined at 3.4 angstrom resolution. This resolvase, activated for recombination by mutations, forms a tetramer whose structure is substantially changed from that of a presynaptic complex between dimeric resolvase and the cleavage site DNA. Because the two cleaved DNA duplexes that are to be recombined lie on opposite sides of the core tetramer, large movements of both protein and DNA are required to achieve strand exchange. The two dimers linked to the DNAs that are to be recombined are held together by a flat interface. This may allow a 180 degrees rotation of one dimer relative to the other in order to reposition the DNA duplexes for strand exchange.
About this Structure
1ZR4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structure of a synaptic gammadelta resolvase tetramer covalently linked to two cleaved DNAs., Li W, Kamtekar S, Xiong Y, Sarkis GJ, Grindley ND, Steitz TA, Science. 2005 Aug 19;309(5738):1210-5. Epub 2005 Jun 30. PMID:15994378
Page seeded by OCA on Mon Mar 31 01:40:36 2008
