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4xci

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Revision as of 09:06, 1 November 2017

Crystal structure of a hexadecameric TF55 complex from S. solfataricus, crystal form II

Structural highlights

4xci is a 2 chain structure with sequence from Sulso. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[THSB_SULSO] Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. [THSA_SULSO] Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

Publication Abstract from PubMed

Chaperonins are essential biological complexes assisting protein folding in all kingdoms of life. Whereas homooligomeric bacterial GroEL binds hydrophobic substrates non-specifically, the heterooligomeric eukaryotic CCT binds specifically to distinct classes of substrates. Sulfolobales, which survive in a wide range of temperatures, have evolved three different chaperonin subunits (alpha, beta, gamma) that form three distinct complexes tailored for different substrate classes at cold, normal, and elevated temperatures. The larger octadecameric beta complexes cater for substrates under heat stress, whereas smaller hexadecameric alphabeta complexes prevail under normal conditions. The cold-shock complex contains all three subunits, consistent with greater substrate specificity. Structural analysis using crystallography and electron microscopy reveals the geometry of these complexes and shows a novel arrangement of the alpha and beta subunits in the hexadecamer enabling incorporation of the gamma subunit.

Structural and Functional Insights into the Evolution and Stress Adaptation of Type II Chaperonins.,Chaston JJ, Smits C, Aragao D, Wong AS, Ahsan B, Sandin S, Molugu SK, Molugu SK, Bernal RA, Stock D, Stewart AG Structure. 2016 Jan 28. pii: S0969-2126(16)00010-1. doi:, 10.1016/j.str.2015.12.016. PMID:26853941^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Chaston JJ, Smits C, Aragao D, Wong AS, Ahsan B, Sandin S, Molugu SK, Molugu SK, Bernal RA, Stock D, Stewart AG. Structural and Functional Insights into the Evolution and Stress Adaptation of Type II Chaperonins. Structure. 2016 Jan 28. pii: S0969-2126(16)00010-1. doi:, 10.1016/j.str.2015.12.016. PMID:26853941 doi:http://dx.doi.org/10.1016/j.str.2015.12.016

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4xci"

@@ Line 3: / Line 3: @@
 <StructureSection load='4xci' size='340' side='right' caption='[[4xci]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4xci]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus_(strain_atcc_35092_/_dsm_1617_/_jcm_11322_/_p2) Sulfolobus solfataricus (strain atcc 35092 / dsm 1617 / jcm 11322 / p2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XCI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4xci]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulso Sulso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XCI FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xci OCA], [http://pdbe.org/4xci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xci RCSB], [http://www.ebi.ac.uk/pdbsum/4xci PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xci OCA], [http://pdbe.org/4xci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xci RCSB], [http://www.ebi.ac.uk/pdbsum/4xci PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xci ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 21: / Line 21: @@
 __TOC__
 </StructureSection>
+[[Category: Sulso]]
 [[Category: Chaston, J J]]
 [[Category: Smits, C]]

4xci

From Proteopedia

Revision as of 09:06, 1 November 2017

Crystal structure of a hexadecameric TF55 complex from S. solfataricus, crystal form II

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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